TRPC3/6-IN-1

Modify Date: 2024-04-06 19:46:59

TRPC3/6-IN-1 structure	Common Name	TRPC3/6-IN-1
	CAS Number	736945-96-3	Molecular Weight	365.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₉N₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TRPC3/6-IN-1

TRPC3/6-IN-1 is a potent selectivity and orally active molecule blocker of the canonical transient receptor channels (TRPC3/6), has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. TRPC3/6-IN-1 can be used for the research of chronic models of heart failure[1].

Name	TRPC3/6-IN-1

Description	TRPC3/6-IN-1 is a potent selectivity and orally active molecule blocker of the canonical transient receptor channels (TRPC3/6), has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. TRPC3/6-IN-1 can be used for the research of chronic models of heart failure[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cardiovascular Disease
Target	hTRPC3:1260 nM (IC50) hTRPC6:500 nM (IC50)
In Vitro	TRPC3/6-IN-1 has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively[1].
In Vivo	TRPC3/6-IN-1 has good blocking activity for TRPC3 and TRPC6 in rats[1]. Pharmacokinetic Parameters of TRPC3/6-IN-1 in rats [1]. Compd Dose(iv)(mg/kg) Cmax(iv)(ng/ml) CL(iv)(ml/min/kg) MRT(iv)(h) DNAUC(iv)(h•kg/L) %F 3 0.93 250 120 0.3 0.14 ~1
References	[1]. David G Washburn, et al. The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4979-84.

Molecular Formula	C₂₀H₁₉N₃O₂S
Molecular Weight	365.45

TRPC3/6-IN-1

Use of TRPC3/6-IN-1

Names

TRPC3/6-IN-1 Biological Activity

Chemical & Physical Properties