HDAC1/6-IN-1

Modify Date: 2024-01-29 00:51:24

HDAC1/6-IN-1 structure	Common Name	HDAC1/6-IN-1
	CAS Number	2630989-02-3	Molecular Weight	591.74
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₄₅N₇O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HDAC1/6-IN-1

HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor of GLP, HDAC6 and HDAC1, with IC50 values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 induces cancer cell apoptosis, G0/G1 cell cycle arrest, and blocks migration and invasion[1].

Name	HDAC1/6-IN-1

Description	HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor of GLP, HDAC6 and HDAC1, with IC50 values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 induces cancer cell apoptosis, G0/G1 cell cycle arrest, and blocks migration and invasion[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC6:13 nM (IC50) HDAC1:89 nM (IC50)
References	[1]. Zheng H, et al. Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents. Bioorg Med Chem. 2022 Jan 1;53:116524.

Molecular Formula	C₃₂H₄₅N₇O₄
Molecular Weight	591.74

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HDAC1/6-IN-1

Use of HDAC1/6-IN-1

Names

HDAC1/6-IN-1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.