6(5H)-菲啶酮

6(5H)-Phenanthridinone 是一种有效的 PARP-1 抑制剂和免疫调节剂。6(5H)-Phenanthridinone 抑制细胞增殖,可用于癌症研究。

[ 描述 ]:

[ 相关类别 ]:

[参考文献]

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
274.8±7.0 °C at 760 mmHg

[ 熔点 ]:
290-292 °C(lit.)

[ 分子式 ]:
C₁₃H₉NO

[ 分子量 ]:
195.22

[ 闪点 ]:
158.7±3.1 °C

[ 精确质量 ]:
195.068420

[ PSA ]:
32.86000

[ LogP ]:
2.81

[ 外观性状 ]:
固体;White to Light yellow to Light orange powder to crystal

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.642

[ 储存条件 ]:
2-8°C

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

SG0370000

CHEMICAL NAME :

6(5H)-Phenantridinone

CAS REGISTRY NUMBER :

1015-89-0

LAST UPDATED :

199410

DATA ITEMS CITED :

1

MOLECULAR FORMULA :

C13-H9-N-O

MOLECULAR WEIGHT :

195.23

WISWESSER LINE NOTATION :

T B666 HMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :

Mutation in microorganisms

TEST SYSTEM :

Bacteria - Salmonella typhimurium

DOSE/DURATION :

10 ug/plate

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: LMF-84

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
SG0370000

[ 海关编码 ]:
2933990090

详细合成路线

6(5H)-菲啶酮上游产品

6(5H)-菲啶酮下游产品

以芴酮为原料，与叠氮酸(HN—N+≡N)通过施密特重排反应来合成。亦可用芴酮肟与五氯化磷或多聚磷酸发生贝克曼重排制取。

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors.

Bioorg. Med. Chem. Lett. 19 , 2444-7, (2009)

Benz[b]oxepines 4a-g and 12-oxobenzo[c]phenanthridines 5a-d were designed and synthesized as constrained forms of 3-arylisoquinolines through an intramolecular radical cyclization reaction. Radical cy...

Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.

J. Pharmacol. Exp. Ther. 305(3) , 943-9, (2003)

Excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme catalyzing the transfer of ADP-ribose units from NAD to acceptor proteins, induces cellular energy failure by NAD and A...

Total synthesis of 7-deoxypancratistatin-1-carboxaldehyde and carboxylic acid via solvent-free intramolecular aziridine opening: phenanthrene to phenanthridone cyclization strategy.

Org. Lett. 10(3) , 361-4, (2008)

Solid-state silica-gel-catalyzed opening of aziridine 6 provided phenanthrene 7, whose oxidative cleavage, recyclization, and further elaboration furnished the C-1 aldehyde and carboxylic acid derivat...

更多文献

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：6(5H)-菲啶酮

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥248.0/1g ￥958.0/5g

联系人：刘佳

产品详情：6(5H)-菲啶酮

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公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：6(5H)-Phenanthridinone

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公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥5880.0/25mg ￥436.0/1mg ￥1524.0/5mg ￥需询单/5mg

联系人：李先生

产品详情：6(5H)-Phenanthridinone

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥29.9/1g ￥296.9/25g ￥107.9/5g ￥需询单/1g

联系人：阿拉丁

产品详情：6-(5H)-菲啶酮

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