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Lorglumide钠盐

Lorglumide钠盐用途

Lorglumide sodium salt (CR-1409 sodium salt) 是一种有效的胆囊收缩素(CCK)受体拮抗剂。

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Lorglumide钠盐名称

[ CAS 号 ]:
1021868-76-7

[ 中文名 ]:
Lorglumide钠盐

[ 英文名 ]:
Lorglumide sodium salt

[英文别名 ]:

MFCD00083183

Lorglumide钠盐生物活性

[ 描述 ]:

Lorglumide sodium salt (CR-1409 sodium salt) 是一种有效的胆囊收缩素(CCK)受体拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胆囊收缩素受体

研究领域 >> 代谢疾病

[ 靶点 ]

CCK[1]

[参考文献]

[1]. Scarpignato C, et al. Effect of a new potent CCK antagonist, lorglumide, on caerulein- and bombesin-induced pancreatic secretion and growth in the rat. Br J Pharmacol. 1989 Mar;96(3):661-9.

Lorglumide钠盐物理化学性质

[ 分子式 ]:
C₂₂H₃₁Cl₂N₂NaO₄

[ 分子量 ]:
481.388

[ 精确质量 ]:
480.155853

[ 储存条件 ]:
2-8℃

Lorglumide钠盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
SA3680700

Lorglumide钠盐文献

Different downstream signalling of CCK1 receptors regulates distinct functions of CCK in pancreatic beta cells.

Br. J. Pharmacol. 172 , 5050-67, (2015)

Cholecystokinin (CCK) is secreted by intestinal I cells and regulates important metabolic functions. In pancreatic islets, CCK controls beta cell functions primarily through CCK1 receptors, but the si...

Involvement of different subtypes of cholecystokinin receptors in opioid antinociception in the mouse.

Peptides 16(7) , 1229-34, (1995)

Various doses of sulfated cholecystokinin octapeptide (CCK-8s) injected intracerebroventricularly (ICV) alone did not show any antinociceptive effect. CCK-8s (0.01-1 ng) pretreated ICV for 10 min dose...

Expression of the transcription factor Egr-1 in pancreatic acinar cells following stimulation of cholecystokinin or Gαq-coupled designer receptors.

Cell Physiol. Biochem. 33(5) , 1411-25, (2014)

BACKGOUND/AIMS: The injection of cerulein, an analogue of the pancreatic secretagogue cholecystokinin (CCK), induces acute pancreatitis in mice that is accompanied by the synthesis of the transcriptio...

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