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红景天苷

红景天苷用途

Salidroside 是一种脯氨酰内肽酶 (prolyl endopeptidase) 抑制剂。Salidroside 可通过激活 mTOR 信号缓解肿瘤恶病质小鼠模型中的恶病质症状。

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红景天苷名称

[ CAS 号 ]:
10338-51-9

[ 中文名 ]:
红景天苷

[ 英文名 ]:
Salidroside

[中文别名 ]:

[英文别名 ]:

SALIDROSIDE RHODIOLOSIDE
MFCD00210553
2-(4-Hydroxyphenyl)ethyl α-D-glucopyranoside
RHODIOLOSIDE
Salisorosides Rosavin
Salidroside
RhodiolaCrenulataExtract
rhodosin
TWEEN 20 EXTRA PURE
β-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl

红景天苷生物活性

[ 描述 ]:

Salidroside 是一种脯氨酰内肽酶 (prolyl endopeptidase) 抑制剂。Salidroside 可通过激活 mTOR 信号缓解肿瘤恶病质小鼠模型中的恶病质症状。

[ 相关类别 ]:

信号通路 >> PI3K/Akt/mTOR 信号通路 >> mTOR

研究领域 >> 其他

天然产物 >> 糖和糖苷

[ 靶点 ]

mTOR

[体外研究]

红景天苷(100μM)抑制脯氨酰内肽酶(PEP)活性(10.6±1.9％)。脯氨酰内肽酶是一种在含有脯氨酸的神经肽酶的代谢中起作用的酶,其被认为参与学习和记忆[1]。红景天甙是在R. rosea L中发现的主要苯丙烷苷之一,在许多国家几乎每天作为营养补充剂食用,并且已被确定具有潜在的抗疲劳和缺氧,抗衰老和抗阿尔茨海默病活动。红景天甙可通过增加mTOR,p-mTOR和MyHC表达来改善肌肉营养[2]。将SH-SY5Y细胞暴露于0-600μMMPP+ 12-48小时,结果显示MPP +以浓度和时间依赖性方式导致细胞活力显着降低。将细胞用25-100μM红景天苷(Sal)预处理24小时,然后暴露于500μMMPP+另外24小时。红景天苷浓度依赖性地阻止MPP +诱导的细胞活力降低。膜联蛋白V/PI染色是检测凋亡细胞的常用方法。红景天甙显着降低MPP +处理的膜联蛋白V/PI染色细胞的数量,其浓度依赖性。凋亡细胞也可以通过Hoechst染色进行形态学评估。在Hoechst染色中,凋亡细胞的特征在于核大小减小,染色质浓缩,强荧光和核碎裂。红景天甙显着抑制MPP +诱导的SH-SY5Y细胞中染色质浓缩,强荧光和核碎裂的增加[3]。

[体内研究]

红景天甙是从药用植物红景天提取的天然抗氧化剂。红景天甙(100mg/kg /天)对db/db小鼠显示出强烈的葡萄糖降低作用,其类似于二甲双胍(200mg/kg /天)的作用。因此,使用剂量为100 mg/kg /天的红景天苷[4]。

[细胞实验]

将SH-SY5Y细胞以每孔1×10 4个细胞接种于96孔板中。在用红景天苷（25-100μM）和MPP +处理后，通过MTT测定法测量细胞活力。简言之，将细胞与500μg/ mL MTT在37℃下孵育4小时。之后，除去培养基并加入150μLDMSO并进行振荡10分钟。在酶标仪中在570nm处测量吸光度，结果表示为对照的倍数[3]。

[动物实验]

小鼠[4]给4周龄雄性C57BL / 6小鼠喂食高脂肪饮食（HFD）（n = 16）或正常饲料（n = 8）。在HFD 10周后，通过管饲法每天一次开始红景天苷干预（100mg / kg /天），持续5周。对照组给予载体（盐水）。使用4周龄雄性C57B1 / KsJ（BKS）小鼠（野生型，n = 8）和BKS.Cg-Dock7m + / + Leprdb / J（db / db）小鼠（n = 16）。红景天苷（100mg / kg /天）通过强饲法口服给药，每天一次，持续5周。对照组给予载体（盐水）。每5天监测小鼠的空腹血糖和体重。使用Glucometer对从尾静脉抽取的血液进行葡萄糖测量。

[参考文献]

[1]. Fan W, et al. Prolyl endopeptidase inhibitors from the underground part of Rhodiola sachalinensis. Chem Pharm Bull (Tokyo). 2001 Apr;49(4):396-401.

[2]. Chen X, et al. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activatingmTOR signalling. J Cachexia Sarcopenia Muscle. 2016 May;7(2):225-32.

[3]. Wu L, et al. Salidroside Protects against MPP+-Induced Neuronal Injury through DJ-1-Nrf2 Antioxidant Pathway. Evid Based Complement Alternat Med. 2017;2017:5398542.

[4]. Ju L, et al. Salidroside, A Natural Antioxidant, Improves β-Cell Survival and Function via Activating AMPK Pathway. Front Pharmacol. 2017 Oct 18;8:749.

[相关活性小分子]

红景天苷物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
549.5±50.0 °C at 760 mmHg

[ 分子式 ]:
C₁₄H₂₀O₇

[ 分子量 ]:
300.304

[ 闪点 ]:
286.2±30.1 °C

[ 精确质量 ]:
300.120911

[ PSA ]:
119.61000

[ LogP ]:
-1.23

[ 外观性状 ]:
红色-棕色细粉末

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.629

[ 储存条件 ]:
?20°C

红景天苷MSDS

详细MSDS(安全技术说明书)

红景天苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ5901900

CHEMICAL NAME :: beta-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl

CAS REGISTRY NUMBER :: 10338-51-9

LAST UPDATED :: 199503

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H20-O7

MOLECULAR WEIGHT :: 300.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28600 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 19,229,1988

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红景天苷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
LZ5901900

[ 海关编码 ]:
2932999099

红景天苷合成路线

详细合成路线

红景天苷上下游产品

红景天苷上游产品

红景天苷下游产品

红景天苷海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

红景天苷文献

A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: fabrication, characterization and properties for controlled release of salidroside.

Int. J. Pharm. 446(1-2) , 153-9, (2013)

A novel pH-responsive nano-carrier MSNs-PAA, possessing mesoporous silica nanoparticles (MSNs) cores and poly(acrylic acid) (PAA) shell-layers, was developed for controlled release of salidroside. The...

Inhibitory effects of salidroside and paeonol on tyrosinase activity and melanin synthesis in mouse B16F10 melanoma cells and ultraviolet B-induced pigmentation in guinea pig skin.

Phytomedicine 20(12) , 1082-7, (2013)

Salidroside, the major active component of Rhodiola rosea, a herb with antioxidant, free radical scavenging and tyrosinase inhibitory effects, has been recently reported in protecting the kerationcyte...

Salidroside protects retinal endothelial cells against hydrogen peroxide-induced injury via modulating oxidative status and apoptosis.

Biosci. Biotechnol. Biochem. 79 , 1406-13, (2015)

Oxidative stress can cause injury in retinal endothelial cells. Salidroside is a strong antioxidative and cytoprotective supplement in Chinese traditional medicine. In this study, we investigated the ...

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