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马来酸二丁酯

马来酸二丁酯用途

马来酸二丁酯是马来酸的二酯,可作为药物合成的中间体。马来酸二丁酯可增强小鼠对异硫氰酸荧光素的接触致敏性[1]。

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马来酸二丁酯名称

[ CAS 号 ]:
105-76-0

[ 中文名 ]:
顺丁烯二酸二丁酯

[ 英文名 ]:
n-Butyl fumarate

[中文别名 ]:

马来酸二丁酯

[英文别名 ]:

n-Butyl fumarate
maleic acid di-n-butyl ester
Di-n-butyl maleate
dibutyl 2-methylenesuccinate
Butanedioic acid,methylene-,dibutyl ester
2-methylenesuccinic acid dibutyl ester
Dibutyl (2E)-2-butenedioate
EINECS 203-328-4
Itaconic Acid Dibutyl Ester
MFCD00009447

马来酸二丁酯生物活性

[ 描述 ]:

马来酸二丁酯是马来酸的二酯,可作为药物合成的中间体。马来酸二丁酯可增强小鼠对异硫氰酸荧光素的接触致敏性[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Matsuoka T, et, al. Dibutyl Maleate and Dibutyl Fumarate Enhance Contact Sensitization to Fluorescein Isothiocyanate in Mice. Biol Pharm Bull. 2016;39(2):272-7.

马来酸二丁酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
280.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-85°C

[ 分子式 ]:
C₁₂H₂₀O₄

[ 分子量 ]:
228.285

[ 闪点 ]:
136.4±18.2 °C

[ 精确质量 ]:
228.136154

[ PSA ]:
52.60000

[ LogP ]:
3.81

[ 外观性状 ]:
透明无色至略淡黄色液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.452

[ 储存条件 ]:
室温

[ 水溶解性 ]:
insoluble

[ 凝固点 ]:
<-85℃

马来酸二丁酯MSDS

马来酸二丁酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON0875000

CHEMICAL NAME :: Maleic acid, dibutyl ester

CAS REGISTRY NUMBER :: 105-76-0

BEILSTEIN REFERENCE NO. :: 1726634

LAST UPDATED :: 199806

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C12-H20-O4

MOLECULAR WEIGHT :: 228.32

WISWESSER LINE NOTATION :: 4OV1U1VO4 -C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/27/1963 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 2,19,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 2,19,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1029 No. of Facilities: 178 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 4094 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1029 No. of Facilities: 37 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 402 (estimated)

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马来酸二丁酯安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H373

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R43;R51/53

[ 安全声明 (欧洲) ]:
S26-S36-S61-S37-S29-S24

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
ON0875000

[ 包装等级 ]:
I; II; III

[ 海关编码 ]:
2917190090

马来酸二丁酯合成路线

马来酸二丁酯上下游产品

马来酸二丁酯上游产品

马来酸二丁酯下游产品

马来酸二丁酯制备

1.以顺丁烯二酸酐和丁醇为原料，在硫酸催化下进行酯化，反应产物经中和、水洗、脱醇、蒸馏、过滤而得成品。顺酐与甲醇、乙醇、辛醇、异辛醇或壬醇等进行反应，即得相应的马来酸二烷基酯。原料消耗定额：顺丁烯二酸酐（95%）400kg/t、丁醇820kg/t。

精制方法：用稀碳酸钠溶液洗涤，无水碳酸钾或硫酸钠干燥后减压精馏。

2.制法：

于装有搅拌器、分水器、温度计的反应瓶中，依次加入氨基磺酸0.5g，顺丁烯二酸酐（2）（0.1mol），正丁醇0.25mol，甲苯30mL。搅拌下加热回流，反应中生成的水不断在分水器中集结，直至水量不再增加，约需2h。分出水层，并继续加热蒸出甲苯。此时催化剂可析出。冷后过滤，减压蒸馏，收集142℃/1.5kPa或126℃/0.8kPa的馏分，得顺丁烯二酸二丁酯^①（1）20g，收率92%。注：①也可用强酸性离子交换树脂作反应催化剂，酯的收率约90%。

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马来酸二丁酯海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

马来酸二丁酯文献

Designing greener plasticizers: Effects of alkyl chain length and branching on the biodegradation of maleate based plasticizers.

Chemosphere 134 , 106-12, (2015)

The ubiquitous presence of the plasticizer di (2-ethylhexyl) phthalate (DEHP) in the environment is of concern due to negative biological effects associated with it and its metabolites. In particular,...

Composition-explicit distillation curves of diesel fuel with glycol ether and glycol ester oxygenates: fuel analysis metrology to enable decreased particulate emissions.

Environ. Sci. Technol. 42(20) , 7682-9, (2008)

We recently introduced several important improvements in the measurement of distillation curves of complex fluids. The modifications to the classical measurement provide for (1) a composition-explicit...

Biodegradation of potential diesel oxygenate additives: dibutyl maleate (DBM), and tripropylene glycol methyl ether (TGME).

Chemosphere 52(5) , 861-8, (2003)

The addition of oxygen-bearing compounds to diesel fuel considerably reduces particulate emissions. TGME and DBM have been identified as possible diesel additives based on their physicochemical charac...

更多文献

马来酸二丁酯

马来酸二丁酯用途

马来酸二丁酯名称

马来酸二丁酯生物活性

马来酸二丁酯物理化学性质

马来酸二丁酯MSDS

详细MSDS(安全技术说明书)

马来酸二丁酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

马来酸二丁酯安全信息

马来酸二丁酯合成路线

详细合成路线

马来酸二丁酯上下游产品

马来酸二丁酯上游产品

马来酸二丁酯下游产品

马来酸二丁酯制备

马来酸二丁酯海关

马来酸二丁酯文献

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