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N-羟基琥珀酰亚胺磺酸钠盐

N-羟基琥珀酰亚胺磺酸钠盐用途

N-Hydroxysulfosuccinimide (sodium) 是一种不可降解 (non-cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

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N-羟基琥珀酰亚胺磺酸钠盐名称

[ CAS 号 ]:
106627-54-7

[ 中文名 ]:
N-羟基琥珀酰亚胺磺酸钠盐

[ 英文名 ]:
N-Hydroxysulfosuccinimide sodium

[中文别名 ]:

[英文别名 ]:

Sodium 1-hydroxy-2,5-dioxopyrrolidine-3-sulfonate
N-Hydroxysulfosuccinimide sodiumsalt
Sodium 1-hydroxy-2,5-dioxo-3-pyrrolidinesulfonate
sodium,1-hydroxy-2,5-dioxopyrrolidine-3-sulfonate
N-Hydroxysulfosuccinimide Sodium Salt
MFCD00217065

N-羟基琥珀酰亚胺磺酸钠盐生物活性

[ 描述 ]:

N-Hydroxysulfosuccinimide (sodium) 是一种不可降解 (non-cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 抗体- 药物偶联物 >> ADC连接器

[ 靶点 ]

Non-cleavable

[体外研究]

ADC由抗体组成,抗体通过ADC连接体连接ADC细胞毒素[1]。

[参考文献]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

N-羟基琥珀酰亚胺磺酸钠盐物理化学性质

[ 熔点 ]:
250 °C (dec.)(lit.)

[ 分子式 ]:
C₄H₄NNaO₆S

[ 分子量 ]:
217.132

[ 精确质量 ]:
216.965698

[ PSA ]:
123.19000

[ 外观性状 ]:
白色结晶固体

[ 储存条件 ]:
0-6°C

N-羟基琥珀酰亚胺磺酸钠盐MSDS

详细MSDS(安全技术说明书)

N-羟基琥珀酰亚胺磺酸钠盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2925190090

N-羟基琥珀酰亚胺磺酸钠盐海关

[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

N-羟基琥珀酰亚胺磺酸钠盐文献

The identification of a novel SIRT6 modulator from Trigonella foenum-graecum using ligand fishing with protein coated magnetic beads.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 968 , 105-11, (2014)

SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases. Thus the identification of compounds that...

Pd-Ir Core-Shell Nanocubes: A Type of Highly Efficient and Versatile Peroxidase Mimic.

ACS Nano 9 , 9994-10004, (2015)

Peroxidase mimics with dimensions on the nanoscale have received great interest as emerging artificial enzymes for biomedicine and environmental protection. While a variety of peroxidase mimics have b...

Interprotein Coupling Enhances the Electrocatalytic Efficiency of Tobacco Peroxidase Immobilized at a Graphite Electrode.

Anal. Chem. 87 , 10807-14, (2015)

Covalent immobilization of enzymes at electrodes via amide bond formation is usually carried out by a two-step protocol, in which surface carboxylic groups are first activated with the corresponding c...

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