N-甲基哌嗪
N-甲基哌嗪结构式
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常用名 | N-甲基哌嗪 | 英文名 | methylpiperazine |
|---|---|---|---|---|
| CAS号 | 109-01-3 | 分子量 | 100.162 | |
| 密度 | 0.9±0.1 g/cm3 | 沸点 | 138.0±8.0 °C at 760 mmHg | |
| 分子式 | C5H12N2 | 熔点 | -6 °C | |
| MSDS | 中文版 美版 | 闪点 | 42.2±0.0 °C | |
| 符号 |
GHS02, GHS05, GHS06 |
信号词 | Danger |
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Synthesis and antitumor activities of some new N1-(flavon-6-yl)amidrazone derivatives.
Arch. Pharm. (Weinheim) 347(6) , 415-22, (2014) A new series of N1-(flavon-6-yl)amidrazones were synthesized by reacting the hydrazonoyl chloride derived from 6-aminoflavone with the appropriate sec-cyclic amines. The antitumor activities of these compounds were evaluated on breast cancer (MCF-7) and leuke... |
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Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.
Bioorg. Med. Chem. 23(9) , 2024-34, (2015) Recently we described a novel pyranopyridine inhibitor (MBX2319) of RND-type efflux pumps of the Enterobacteriaceae. MBX2319 (3,3-dimethyl-5-cyano-8-morpholino-6-(phenethylthio)-3,4-dihydro-1H-pyrano[3,4-c]pyridine) is structurally distinct from other known G... |
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Synthesis of 1H-1,2,3-triazole linked aryl(arylamidomethyl) - dihydrofurocoumarin hybrids and analysis of their cytotoxicity.
Eur. J. Med. Chem. 100 , 119-28, (2015) A series of 2-(4-R-triazolyl)substituted 3-oxo-2,3-dihydrofurocoumarins have been synthesized by a regioselective cycloaddition of 2-azidooreoselone 1 or 2-azido-9-[(4-methylpiperazin-1-yl)methyl]oreoselone 2 with various alkynes in the presence of Cu(II)/asc... |
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Mechanistic insights into the Pd(BINAP)-catalyzed amination of aryl bromides: kinetic studies under synthetically relevant conditions.
J. Am. Chem. Soc. 124(47) , 14104-14, (2002) Kinetic studies using reaction calorimetry were carried out under synthetically relevant conditions to study the mechanism of the amination of bromobenzene with primary and secondary amines using Pd(2)(dba)(3)/BINAP mixtures as well as preformed (dba)Pd(BINAP... |
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The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells.
Drug Des. Devel. Ther. 9 , 1027-62, (2015) Danusertib (Danu) is a pan-inhibitor of Aurora kinases and a third-generation breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (Bcr-Abl) tyrosine kinase inhibitor, but its antitumor effect and underlying mechanisms in the treatment o... |
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Chalcogenides of the aminomethylphosphines derived from 1-methylpiperazine, 1-ethylpiperazine and morpholine: NMR, DFT and structural studies for determination of electronic and steric properties of the phosphines.
Dalton Trans. 39(32) , 7547-55, (2010) Chalcogenide derivatives of three aminomethylphosphines: P(CH2N(CH2CH2)2NCH3)3 (1), P(CH2N(CH2CH2)2NCH2CH3)3 (2) and P(CH2N(CH2CH2)2O)3 (3) were prepared: oxides--OP(CH2N(CH2CH2)2NCH3)3 (4), OP(CH2N(CH2CH2)2NCH2CH3)3 (5), OP(CH2N(CH2CH2)2O)3 (6), sulfides--SP... |
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The hydrolysis kinetics of monobasic and dibasic aminoalkyl esters of ketorolac.
Drug Dev. Ind. Pharm. 39(9) , 1346-56, (2013) Six aminoethyl and aminobutyl esters of ketorolac containing 1-methylpiperazine (MPE and MPB), N-acetylpiperazine (APE and APB) or morpholine (ME and MB), were synthesized and their hydrolysis kinetics were studied. The hydrolysis was studied at pH 1 to 9 (fo... |
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IgE antibodies against piperazine and N-methyl-piperazine in two asthmatic subjects.
Int. Arch. Allergy Appl. Immunol. 79(3) , 259-62, (1986) The presence of specific IgE antibodies against conjugates between human serum albumin and piperazine, a compound previously known to cause occupational asthma, and N-methyl-piperazine, respectively, was demonstrated by RAST, RAST inhibition and skin prick te... |
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Bacterially catalysed N-nitrosation reactions and their relative importance in the human stomach.
Carcinogenesis 8(12) , 1907-12, (1987) Human exposure to endogenously formed N-nitroso compounds has frequently been suggested as a causative factor in carcinogenesis where this is related to chronic bacterial infection such as is seen in gastric achlorhydria. At least two distinct mechanisms of e... |
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Sequence-dependent variation in DNA minor groove width dictates orientational preference of Hoechst 33258 in A-tract recognition: solution NMR structure of the 2:1 complex with d(CTTTTGCAAAAG)(2).
Nucleic Acids Res. 28(3) , 728-35, (2000) The solution structure of the dodecamer duplex d(CTTTTGCAAAAG)(2)and its 2:1 complex with the bis -benzimidazole Hoechst 33258 has been investigated by NMR and NOE-restrained molecular dynamics (rMD) simulations. Drug molecules are bound in each of the two A-... |