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吡硫醇

吡硫醇用途

Pyrithioxin是一种神经动力化合物,促进脑内葡萄糖及氨基酸的代谢,改善全身同化作用,增加颈动脉血流量,改善脑血流。

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吡硫醇名称

[ CAS 号 ]:
1098-97-1

[ 中文名 ]:
吡硫醇

[ 英文名 ]:
Pyrithioxin

[中文别名 ]:

[英文别名 ]:

Epocan
Dipyridoxolyldisulfide
Pyrithioxine
MFCD00151477
Bonifen
Piritinol
Pyridoxine disulfide
Bonol
PYRITINOL
Encefabol

吡硫醇生物活性

[ 描述 ]:

Pyrithioxin是一种神经动力化合物,促进脑内葡萄糖及氨基酸的代谢,改善全身同化作用,增加颈动脉血流量,改善脑血流。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Stoica E, et al. Facilitation through hyperventilation of therapeutic effect of pyrithioxin in cerebral infarct patients. Eur Neurol. 1975;13(4):285-303.

[相关活性小分子]

吡硫醇物理化学性质

[ 密度 ]:
1.448 g/cm3

[ 沸点 ]:
742.8ºC at 760 mmHg

[ 熔点 ]:
54-57 °C(lit.)

[ 分子式 ]:
C₁₆H₂₀N₂O₄S₂

[ 分子量 ]:
368.47100

[ 闪点 ]:
>230 °F

[ 精确质量 ]:
368.08600

[ PSA ]:
157.30000

[ LogP ]:
2.57080

[ 外观性状 ]:
近乎于白色结晶粉末

[ 储存条件 ]:
库房通风低温干燥

吡硫醇MSDS

详细MSDS(安全技术说明书)

吡硫醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT4836666

CHEMICAL NAME :: 4-Pyridinemethanol, 3,3'-(dithiobis(methylene))bis(5-hydroxy-6-methyl-

CAS REGISTRY NUMBER :: 1098-97-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H20-N2-O4-S2

MOLECULAR WEIGHT :: 368.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4598079

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吡硫醇安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
UT4836666

[ 海关编码 ]:
2933399090

吡硫醇海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吡硫醇文献

[The use of encephabol in neurological practice].

Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova 102(6) , 53-6, (2002)

Stability-indicating chemometric methods for the determination of pyritinol dihydrochloride.

Drug Test. Anal. 1(5) , 228-33, (2009)

Three multivariate calibration methods, including classical least square with nonzero intercept (CLS), principal component regression (PCR) and partial least square (PLS), have been used for the deter...

Pyritinol reduces nociception and oxidative stress in diabetic rats

Eur. J. Pharmacol. 590(1-3) , 170-6, (2008)

The purpose of this study was to assess the antinociceptive and antiallodynic effect of pyritinol as well as its possible mechanism of action in diabetic rats. Streptozotocin (50 mg/kg) injection caus...

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吡硫醇