二乙二醇甲醚
二乙二醇甲醚用途
二乙二醇甲醚名称
[ CAS 号 ]:
111-77-3
[ 中文名 ]:
二乙二醇单甲醚
[ 英文名 ]:
Methyl-PEG2-alcohol
[中文别名 ]:
[英文别名 ]:
- 2-(2-Methoxyethoxy)ethanol
- 2-(2-Methoxyethoxy)-Ethanol
- Diglycol monomethyl ether
- Diethylene glycol monomethyl ether
- Ethanol, 2-(2-methoxyethoxy)-
- EINECS 203-906-6
- Methyl carbitol
- 2-(2-Methoxyethoxy)ethanol,Methyldiglycol
- MFCD00002871
二乙二醇甲醚生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
PEGs
[体外研究]
[参考文献]
二乙二醇甲醚物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
194.1±0.0 °C at 760 mmHg
[ 熔点 ]:
−70 °C(lit.)
[ 分子式 ]:
C5H12O3
[ 分子量 ]:
120.147
[ 闪点 ]:
83.9±0.0 °C
[ 精确质量 ]:
120.078644
[ PSA ]:
38.69000
[ LogP ]:
-1.16
[ 外观性状 ]:
液体
[ 蒸汽密度 ]:
4.14 (vs air)
[ 蒸汽压 ]:
0.1±0.8 mmHg at 25°C
[ 折射率 ]:
1.413
[ 储存条件 ]:
包装完整、轻装轻卸,库房通风、远离明火、高温、与氧化剂分开存放
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Hygroscopic. Store under nitrogen.
[ 水溶解性 ]:
Miscible
二乙二醇甲醚MSDS
二乙二醇甲醚毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KL6125000
- CHEMICAL NAME :
- Ethanol, 2-(2-methoxyethoxy)-
- CAS REGISTRY NUMBER :
- 111-77-3
- BEILSTEIN REFERENCE NO. :
- 1697812
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 26
- MOLECULAR FORMULA :
- C5-H12-O3
- MOLECULAR WEIGHT :
- 120.17
- WISWESSER LINE NOTATION :
- Q2O2O1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 4/21/1967
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,628,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0520737
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/m3/1H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516703
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2722 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 29,37,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8222 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 29,37,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2611 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 29,37,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 7190 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516797
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2500 uL/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516797
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 4160 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 107 gm/kg/6W-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570960
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5052 mg/kg/30D-C
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Metabolism (Intermediary) - other proteins
- REFERENCE :
- GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 29,37,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 40 gm/kg/4W-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - peptidases
- REFERENCE :
- TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 76,49,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 40 gm/kg/20D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Endocrine - changes in thymus weight Related to Chronic Data - changes in testicular weight
- REFERENCE :
- BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 44,602,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 65 gm/kg/13W-I
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,339,1986 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 19800 mg/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
- REFERENCE :
- AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 24,228,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 21650 mg/kg
- SEX/DURATION :
- female 7-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,430,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 19800 mg/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 24,228,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 6600 mg/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - physical
- REFERENCE :
- AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 24,228,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 32 gm/kg
- SEX/DURATION :
- female 7-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
- REFERENCE :
- EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 57,141,1984
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- DOSE :
- 3250 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 7,68,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83736 No. of Facilities: 9648 (estimated) No. of Industries: 67 No. of Occupations: 47 No. of Employees: 59491 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83736 No. of Facilities: 19501 (estimated) No. of Industries: 134 No. of Occupations: 89 No. of Employees: 290501 (estimated) No. of Female Employees: 50151 (estimated)
二乙二醇甲醚安全信息
[ 危害码 (欧洲) ]:
Xn:Harmful;
[ 风险声明 (欧洲) ]:
R63
[ 安全声明 (欧洲) ]:
S36/37
[ WGK德国 ]:
1
[ RTECS号 ]:
KL6125000
[ 海关编码 ]:
2909440000
二乙二醇甲醚合成路线
二乙二醇甲醚上下游产品
二乙二醇甲醚上游产品
二乙二醇甲醚下游产品
二乙二醇甲醚制备
1.本品是乙二醇单甲醚工业生产的副产品。将环氧乙烷与甲醇混合，经预热后加入反应器。反应温度为150～200℃。反应压力为1.96～3.92MPa，甲醇过量约15%。反应产物除主反应生成的乙二醇单甲醚外，还含有副反应生成的二乙二醇甲醚和三乙二醇甲醚，以及过量的甲醇。经醇回收塔和3个真空精馏塔将四个主要组分分离，得到的甲醇循环使用，并得到乙二醇单甲醚、二乙二醇甲醚和三乙二醇甲醚等产品。
精制方法：用无水硫酸钠或氯化钙干燥后分馏。
2.主要采用环氧乙烷法和乙二醇生产副产回收法。环氧乙烷法:将环氧乙烷水解生成二乙二醇醚,再与甲醇反应而得。乙二醇生产副产回收法:将生产乙二醇的下脚料与甲醇反应,经减压蒸馏而得。
二乙二醇甲醚海关
[ 海关编码 ]: 2909499000
[ 中文概述 ]:
2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%
相关化工产品/化学物质：
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公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：二乙二醇单甲醚
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥128.0/500ml
联系人：刘佳
产品详情：二乙二醇单甲醚
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
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￥29.9/100ml
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￥59.9/500ml
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联系人：阿拉丁
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公司名：上海创赛科技有限公司
区域：上海市嘉定区
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￥81.0/500ml
￥234.0/2500ml
￥673.0/10l
￥37.0/5ml
联系人：夏言
产品详情：[Perfemiker]二乙二醇单甲醚,>99.0%(GC)
公司名：中山市迪欣化工有限公司
区域：中山市三角镇
价格：
￥30.0/1000kg
联系人：陈雪萍
产品详情：二乙二醇甲醚
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相关化合物
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