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三乙二醇单甲醚

三乙二醇单甲醚用途

m-PEG3-alcohol 是一种 PROTAC 连接桥 (PROTAC linker),属于 PEG 类,可用于合成 PROTACs。

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三乙二醇单甲醚名称

[ CAS 号 ]:
112-35-6

[ 中文名 ]:
三甘醇单甲醚

[ 英文名 ]:
m-PEG3-OH

[中文别名 ]:

[英文别名 ]:

UNII-DN0P4Q4I16
Ethanol, 2-(2-(2-methoxyethoxy)ethoxy)-
Triethylene glycol monomethyl ether
3,6,9-Trioxa-1-decanol
Triglycol monomethyl ether
2-(2-(2-Methoxyethoxy)ethoxy)ethanol
Methoxytriglycol
triethylene glycol methyl ether
Methoxytriethylene glycol
2-[2-(2-Methoxyethoxy)ethoxy]ethanol

三乙二醇单甲醚生物活性

[ 描述 ]:

m-PEG3-alcohol 是一种 PROTAC 连接桥 (PROTAC linker),属于 PEG 类,可用于合成 PROTACs。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

PEGs

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白

三乙二醇单甲醚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
233.9±20.0 °C at 760 mmHg

[ 熔点 ]:
-44ºC

[ 分子式 ]:
C₇H₁₆O₄

[ 分子量 ]:
164.199

[ 闪点 ]:
95.3±21.8 °C

[ 精确质量 ]:
164.104858

[ PSA ]:
47.92000

[ LogP ]:
-1.51

[ 外观性状 ]:
黏的无色液体

[ 蒸汽密度 ]:
5.66 (vs air)

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.427

[ 储存条件 ]:
室温

三乙二醇单甲醚MSDS

三乙二醇单甲醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KL6390000

CHEMICAL NAME :: Ethanol, 2-(2-(2-methoxyethoxy)ethoxy)-

CAS REGISTRY NUMBER :: 112-35-6

BEILSTEIN REFERENCE NO. :: 1700198

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C7-H16-O4

MOLECULAR WEIGHT :: 164.23

WISWESSER LINE NOTATION :: Q2O2O2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,634,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,634,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11300 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 7100 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0892 No. of Facilities: 13261 (estimated) No. of Industries: 85 No. of Occupations: 32 No. of Employees: 80404 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0892 No. of Facilities: 2416 (estimated) No. of Industries: 22 No. of Occupations: 29 No. of Employees: 18956 (estimated) No. of Female Employees: 9842 (estimated)

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三乙二醇单甲醚安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
KL6390000

[ 海关编码 ]:
2909499000

三乙二醇单甲醚合成路线

三乙二醇单甲醚上下游产品

三乙二醇单甲醚上游产品

三乙二醇单甲醚下游产品

三乙二醇单甲醚海关

[ 海关编码 ]: 2909499000

[ 中文概述 ]:
2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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Synthesis of uniform cyclodextrin thioethers to transport hydrophobic drugs.

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Methyl and ethyl thioether groups were introduced at all primary positions of α-, β-, and γ-cyclodextrin by nucleophilic displacement reactions starting from the corresponding per-(6-deoxy-6-bromo)cyc...

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