L-青霉胺

L-青霉胺用途

L-Penicillamine is a medication primarily used for the treatment of Wilson's disease. It is also used for people with kidney stones who have high urine cystine levels, rheumatoid arthritis, copper poisoning, and lead poisoning. It is taken by mouth. Common side effects include rash, loss of appetite, nausea, diarrhea, and low blood white blood cell levels. Other serious side effects include liver problems, obliterative bronchiolitis, and myasthenia gravis. It is not recommended in people with lupus erythematosus. Use during pregnancy may result in harm to the baby. Penicillamine works by binding heavy metals such that they can be removed from the body in the urine.

点击显示

L-青霉胺名称

[ CAS 号 ]:
1113-41-3

[ 中文名 ]:
L-青霉胺

[ 英文名 ]:
L-penicillamine

[中文别名 ]:

[英文别名 ]:

EINECS 214-203-9
L(+)-Penicillamine
2-Amino-3-mercapto-3-methylbutanoic acid
3-mercapto-L-valine
3-Sulfanyl-L-valine
L-β,β-Dimethylcysteine
L-Penicillamine
(R)-penicillamine
(±)-penicillamine
DL-Penicillamine

L-青霉胺物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
251.8±35.0 °C at 760 mmHg

[ 熔点 ]:
206ºC (dec.)

[ 分子式 ]:
C₅H₁₁NO₂S

[ 分子量 ]:
149.211

[ 闪点 ]:
106.1±25.9 °C

[ 精确质量 ]:
149.051056

[ PSA ]:
102.12000

[ LogP ]:
0.93

[ 外观性状 ]:
白色-类白色晶体-粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.528

[ 储存条件 ]:
室温

L-青霉胺MSDS

详细MSDS(安全技术说明书)

L-青霉胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YV9445500

CHEMICAL NAME :: Valine, 3-mercapto-, L-

CAS REGISTRY NUMBER :: 1113-41-3

BEILSTEIN REFERENCE NO. :: 1722374

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C5-H11-N-O2-S

MOLECULAR WEIGHT :: 149.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 4 umol/plate

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 34,3725,1985 *** REVIEWS *** TOXICOLOGY REVIEW PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,465,1979

点击显示

L-青霉胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
YV9445500

[ 海关编码 ]:
2930909090

L-青霉胺合成路线

详细合成路线

L-青霉胺上下游产品

L-青霉胺上游产品

L-青霉胺下游产品

L-青霉胺海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

L-青霉胺文献

Circular muscle contraction in the mice rectum plays a key role in morphine-induced constipation.

Neurogastroenterol. Motil. 26(10) , 1396-407, (2014)

Although opioids induce intestinal muscle contraction and provoke constipation, the intestinal region(s) that contribute to the constipation have remained unclear. We report here a region-specific res...

Inhibitors of bacterialN-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity

Bioorg. Med. Chem. Lett. 19 , 6350-2, (2009)

A screen biased toward compounds containing zinc-binding groups (ZBG’s) delivered a number of micromolar inhibitors of DapE from Haemophilus influenzae, including l-captopril (IC 50 = 3.3 μM, K i = 1....

Acetyl- and butyryl-cholinesterase inhibitory activities of the edible brown alga Eisenia bicyclis.

Arch. Pharm. Res. 38 , 1477-87, (2015)

As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory ac...

更多文献