大黄酸-8-葡萄糖苷钙盐

大黄酸-8-葡萄糖苷钙盐用途

Rhein-8-glucoside calcium,一种从 Saussurea lappa 根的 EtOH 提取物中分离得到的蒽醌化合物。Rhein-8-glucoside calcium 是一种 hPTP1B 抑制剂,IC50 值为11.5 μM。Rhein-8-glucoside calcium 具有抗菌作用。

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大黄酸-8-葡萄糖苷钙盐名称

[ CAS 号 ]:
113443-70-2

[ 中文名 ]:
大黄酸-8-O-β-D-葡萄糖苷

[ 英文名 ]:
Rhein-8-glucoside calcium salt

[中文别名 ]:

大黄酸-8-O-Beta-D-葡萄糖苷

[英文别名 ]:

Glucorein
Glucorhein
Rhein-8-glucoside calcium salt
Rhein-8-O-Beta-D-glucopyranoside
8-Glucosylrhein

大黄酸-8-葡萄糖苷钙盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶

研究领域 >> 感染

研究领域 >> 代谢疾病

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

IC50: 11.5 μM (hPTP1B)[1]

[参考文献]

[1]. Li S, et, al. PTP1B inhibitors from Saussrurea lappa. J Asian Nat Prod Res. Apr-May 2006;8(3):281-6.

[2]. Zhang Y, et, al. Effects of Rhein-8-O-β-D-glucopyranoside on the Biofilm Formation of Streptococcus mutans. Curr Microbiol. 2020 Oct 31.

[3]. Zhang LS, et, al. Rhein-8-O-β-D-glucopyranoside inhibited high glucose-induced apoptosis of human mesangial cells by regulating the lincRNA ANRIL/let-7a/TGF-β1/Smad signaling pathway. Exp Ther Med. 2020 Apr;19(4):2871-2878.

大黄酸-8-葡萄糖苷钙盐物理化学性质

[ 沸点 ]:
834.5ºC at 760mmHg

[ 分子式 ]:
C₂₁H₁₆CaO₁₁

[ 分子量 ]:
484.423

[ 闪点 ]:
296.4ºC

[ 精确质量 ]:
484.031860

[ PSA ]:
207.71000

[ 蒸汽压 ]:
1.54E-29mmHg at 25°C

[ 储存条件 ]:
2-8℃

大黄酸-8-葡萄糖苷钙盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB8782000

CHEMICAL NAME :: 2-Anthroic acid, 9,10-dihydro-9,10-dioxo-5-beta-D-glucopyranosyloxy-4- hydroxy-, calcium salt

CAS REGISTRY NUMBER :: 113443-70-2

LAST UPDATED :: 199109

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H17-O11.Ca

MOLECULAR WEIGHT :: 485.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 61,153,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 61,153,1987