< 生产厂家价格 >

二苯基(4-哌啶基)甲醇

二苯基(4-哌啶基)甲醇用途

Azacyclonol即γ-pipradol,有消除精神病患者幻觉的活性。

点击显示

二苯基(4-哌啶基)甲醇名称

[ CAS 号 ]:
115-46-8

[ 中文名 ]:
α,α-二苯基-4-哌啶甲醇

[ 英文名 ]:
Azacyclonol

[中文别名 ]:

[英文别名 ]:

alpha,alpha-Diphenyl-4-piperidinomethanol
4-(α,α Diphenyl) piperidine methanol
Diphenyl(4-piperidinyl)methanol
a,a-Diphenyl-4-piperidinemethanol
γ-Pipradrol
MFCD00066980
Ataractan
4-Piperidinemethanol, α,α-diphenyl-
α,α-Diphenyl-4-piperidinemethanol
α-(4-Piperidyl)benzhydrol

二苯基(4-哌啶基)甲醇生物活性

[ 描述 ]:

Azacyclonol即γ-pipradol,有消除精神病患者幻觉的活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Raeissi, S.D., et al., Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine. Pharm Res, 1997. 14(8): p. 1019-25.

[2]. Ling, K.H., et al., Metabolism of terfenadine associated with CYP3A(4) activity in human hepatic microsomes. Drug Metab Dispos, 1995. 23(6): p. 631-6.

[3]. Brown, D.A. and J.P. Quilliam, The effects of some centrally acting drugs on ganglionic transmission in the cat. Br J Pharmacol Chemother, 1964. 23(2): p. 241-56.

[相关活性小分子]

二苯基(4-哌啶基)甲醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
445.5±40.0 °C at 760 mmHg

[ 熔点 ]:
160-163 °C

[ 分子式 ]:
C₁₈H₂₁NO

[ 分子量 ]:
267.365

[ 闪点 ]:
142.0±18.0 °C

[ 精确质量 ]:
267.162323

[ PSA ]:
32.26000

[ LogP ]:
3.25

[ 外观性状 ]:
白色至淡米色结晶粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.584

[ 储存条件 ]:
室温，干燥

二苯基(4-哌啶基)甲醇MSDS

详细MSDS(安全技术说明书)

二苯基(4-哌啶基)甲醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN0470000

CHEMICAL NAME :: 4-Piperidinemethanol, alpha,alpha-diphenyl-

CAS REGISTRY NUMBER :: 115-46-8

BEILSTEIN REFERENCE NO. :: 0230221

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C18-H21-N-O

MOLECULAR WEIGHT :: 267.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 177 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

点击显示

二苯基(4-哌啶基)甲醇安全信息

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ RTECS号 ]:
TN0470000

[ 海关编码 ]:
29333999

二苯基(4-哌啶基)甲醇合成路线

详细合成路线

二苯基(4-哌啶基)甲醇上下游产品

二苯基(4-哌啶基)甲醇上游产品

二苯基(4-哌啶基)甲醇下游产品

二苯基(4-哌啶基)甲醇海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%