二吲哚马来酰亚胺IV

二吲哚马来酰亚胺IV用途

Bisindolylmaleimide IV (Arcyriarubin A) 是一种有效的蛋白激酶 C (PKC) 抑制剂,其 IC50 范围为 0.1-0.55 μM。Bisindolylmaleimide IV 也抑制 PKA (IC50=3.1-11.8 μM)。Bisindolylmaleimide IV 在细胞培养中,是有效的人巨细胞病毒 (HCMV) 复制的抑制剂,IC50为 0.2 μM。

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二吲哚马来酰亚胺IV名称

[ CAS 号 ]:
119139-23-0

[ 中文名 ]:
双吲哚马来酰亚胺 IV

[ 英文名 ]:
Bisindolylmaleimide IV

[中文别名 ]:

[英文别名 ]:

MFCD00236432
3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione
2,3-bis-(1h-indol-3-yl)-maleimide
3,4-Bis(3-indolyl)maleimide
3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-

二吲哚马来酰亚胺IV生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> PKC

研究领域 >> 感染

信号通路 >> TGF-beta/Smad 信号通路 >> PKC

信号通路 >> 抗感染 >> CMV

[ 靶点 ]

PKC:0.1-0.55 μM (IC50)

HCMV:0.2 μM (IC50)

[体外研究]

双吲哚甲酰亚胺IV(Arcyriarubin A)在1%二甲基亚砜中的IC50为0.1μM,而在10%二甲基亚砜中的IC50为0.55μM,对PKC有抑制作用[1]。

[参考文献]

[1]. Davis PD, et al. Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84.

[2]. Slater MJ, et al. Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg Med Chem. 1999 Jun;7(6):1067-74.

二吲哚马来酰亚胺IV物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
690.1±55.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₁₃N₃O₂

[ 分子量 ]:
327.336

[ 闪点 ]:
371.2±31.5 °C

[ 精确质量 ]:
327.100769

[ PSA ]:
77.75000

[ LogP ]:
3.21

[ 外观性状 ]:
暗红色固体

[ 蒸汽压 ]:
0.0±2.2 mmHg at 25°C

[ 折射率 ]:
1.811

[ 储存条件 ]:
-20℃

二吲哚马来酰亚胺IVMSDS

详细MSDS(安全技术说明书)

二吲哚马来酰亚胺IV安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

二吲哚马来酰亚胺IV合成路线

详细合成路线

二吲哚马来酰亚胺IV上下游产品

二吲哚马来酰亚胺IV上游产品

二吲哚马来酰亚胺IV下游产品

二吲哚马来酰亚胺IV海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

二吲哚马来酰亚胺IV文献

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Am. J. Physiol. Renal Physiol. 302(1) , F159-72, (2012)

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Entry of Newcastle Disease Virus into the host cell: role of acidic pH and endocytosis.

Biochim. Biophys. Acta 1838(1 Pt B) , 300-9, (2014)

Most paramyxoviruses enter the cell by direct fusion of the viral envelope with the plasma membrane. Our previous studies have shown the colocalization of Newcastle Disease Virus (NDV) with the early ...

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