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4-羟基-3-硝基苯胂酸

4-羟基-3-硝基苯胂酸用途

Roxarsone是一种有机砷化合物,广泛用于家禽生产,用作饲料添加剂,以提高增重,提高饲料效率,及作为抗球虫药。
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4-羟基-3-硝基苯胂酸名称

[ CAS 号 ]:
121-19-7

[ 中文名 ]:
洛克沙砷

[ 英文名 ]:
Roxarsone

[中文别名 ]:

[英文别名 ]:

4-羟基-3-硝基苯胂酸生物活性

[ 描述 ]:

Roxarsone是一种有机砷化合物,广泛用于家禽生产,用作饲料添加剂,以提高增重,提高饲料效率,及作为抗球虫药。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 其他

[相关活性小分子]

磺丁基-β-环糊精钠盐 | 环孢霉素A | 2-(3,6-二乙酰氧基-2,7-二氯-9H-氧杂蒽-9-基)苯甲酸 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | GW4869 | 乙莫克舍 | (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫代双(4-(4-(3-氟苯基)-1H-1,-1H-1,2,3-三唑-1-基)-2-(羟甲基)四氢-2H-吡喃-3,5-二醇) | Mitoquinone甲磺酸盐 | GSK2795039 | CBIC2 | BAPTA-AM | AP20187 | GKT137831 | D-(-)-荧光素 | 单响尾蛇毒蛋白

4-羟基-3-硝基苯胂酸物理化学性质

[ 沸点 ]:
537.3±60.0 °C at 760 mmHg

[ 熔点 ]:
≥300 °C(lit.)

[ 分子式 ]:
C6H6AsNO6

[ 分子量 ]:
263.036

[ 闪点 ]:
240.3±21.3 °C

[ 精确质量 ]:
262.941101

[ PSA ]:
123.58000

[ LogP ]:
-0.51

[ 外观性状 ]:
淡黄色晶体或淡黄褐色的粉末

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
<0.1 g/100 mL at 23 ºC

4-羟基-3-硝基苯胂酸MSDS

详细MSDS(安全技术说明书)

4-羟基-3-硝基苯胂酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CY5250000
CHEMICAL NAME :
Benzenearsonic acid, 4-hydroxy-3-nitro-
CAS REGISTRY NUMBER :
121-19-7
BEILSTEIN REFERENCE NO. :
1976533
LAST UPDATED :
199701
DATA ITEMS CITED :
44
MOLECULAR FORMULA :
C6-H6-As-N-O6
MOLECULAR WEIGHT :
263.05
WISWESSER LINE NOTATION :
WNR BQ E-AS-QQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
81 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
66 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Gastrointestinal - other changes Kidney, Ureter, Bladder - interstitial nephritis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
244 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Liver - hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, Bladder - hematuria
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes Blood - hemorrhage
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
34 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Liver - hepatitis (hepatocellular necrosis), diffuse
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - turkey
DOSE/DURATION :
61 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes Blood - hemorrhage
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2647 mg/kg/13W-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11200 mg/kg/14D-C
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1680 mg/kg/14D-C
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8736 mg/kg/13W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - bronchiolar dilation Liver - changes in liver weight Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
3625 mg/kg/13W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight Blood - hemorrhage Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - turkey
DOSE/DURATION :
2019 mg/kg/36D-C
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2920 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
400 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-345,1989 *** REVIEWS *** TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: As,-,1977 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.5 mg(As)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,16,1971 OSHA PEL (Gen Indu):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.2 mg(As)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.05 mg(As)/m3;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.2 mg(As)/m3 JAN 1993 OEL-DENMARK:TWA 0.05 mg(As)/m3 JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.2 mg(As)/m3 JAN 1993 OEL-HUNGARY:STEL 0.5 mg(As)/m3;Carcinogen JAN 1993 OEL-INDIA:TWA 0.2 mg(As)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 mg(As)/m3 JAN 1993 OEL-POLAND:TWA 0.3 mg(As)/m3 JAN 1993 OEL-SWEDEN:TWA 0.03 mg(As)/m3;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(As)/m3;Carcinogen JAN 1993 OEL-THAILAND:TWA 0.5 mg(As)/m3 JAN 1993 OEL-TURKEY:TWA 0.5 mg(As)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 mg(As)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0637 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 124 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0637 No. of Facilities: 210 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 3230 (estimated)
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4-羟基-3-硝基苯胂酸安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H331-H410

[ 警示性声明 ]:
P261-P273-P301 + P310-P311-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R23/25;R50/53

[ 安全声明 (欧洲) ]:
20/21-28-45-60-61

[ 危险品运输编码 ]:
UN 3465 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
CY5250000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2931900029

4-羟基-3-硝基苯胂酸合成路线

详细合成路线

4-羟基-3-硝基苯胂酸上下游产品

4-羟基-3-硝基苯胂酸上游产品

4-羟基-3-硝基苯胂酸下游产品

4-羟基-3-硝基苯胂酸制备

1.由对羟基苯胂酸经硝化而得。将对羟基苯胂酸及硫酸加入反应锅内，搅拌冷却至0℃以下，缓缓加入混酸，继续搅拌1h，放入冰水中析出沉淀，过滤，干燥，得4-羟基-3-硝基苯胂酸。

2.由对羟基苯胺为原料经重氮化、胂化、硝化制得；还可以苯酚为原料经胂化、硝化制得。
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4-羟基-3-硝基苯胂酸海关

[ 海关编码 ]: 2931900029

[ 中文概述 ]:
2931900029 3-硝基-4-羟基苯胂酸〔4-羟基-3-硝基苯胂酸〕。监管条件:X(有毒化学品环境管理放行通知单)。增值税率:17.0%。退税率:0.0%。最低关税:6.5%。普通关税:30.0%

[ Summary ]:
2931900029 (4-hydroxy-3-nitrophenyl)arsonic acid。supervision conditions:x(environment control release notice for poisonous chemicals)。VAT:17.0%。tax rebate rate:0.0%。MFN tarrif:6.5%。general tariff:30.0%

4-羟基-3-硝基苯胂酸文献

Degradation of roxarsone in a silt loam soil and its toxicity assessment.

Chemosphere 112 , 128-33, (2014)

The land application of poultry or swine litter, containing large amounts of roxarsone, causes serious arsenic pollution in soil. Understanding biotransformation process of roxarsone and its potential...

Retention of phenylarsenicals in soils derived from volcanic materials.

J. Hazard. Mater. 186(2-3) , 1328-34, (2011)

Sorption of phenylarsenicals including 4-hydroxy-3-nitrophenylarsonic acid (roxarsone), an animal feed additive widely used for growth stimulation, on soils was investigated in batch systems. Phenylar...

Characterization of Salmonella enterica isolates from turkeys in commercial processing plants for resistance to antibiotics, disinfectants, and a growth promoter.

Foodborne Pathog. Dis. 8(5) , 593-600, (2011)

Salmonella enterica isolates from turkeys in two commercial processing plants (1 and 2) were characterized for susceptibility to antibiotics, disinfectants, and the organoarsenical growth promoter, 4-...


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相关药品：

推荐生产厂家/供应商：

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Roxarsone

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥39.0/5g ￥1258.0/500g ￥129.0/25g ￥359.0/100g

联系人：阿拉丁李高志

产品详情：4-羟基-3-硝基苯胂酸

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【4-羟基-3-硝基苯胂酸】化源网提供4-羟基-3-硝基苯胂酸CAS号121-19-7，4-羟基-3-硝基苯胂酸MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询4-羟基-3-硝基苯胂酸上化源网，专业又轻松。>>电脑版：4-羟基-3-硝基苯胂酸

标题：4-羟基-3-硝基苯胂酸_MSDS_用途_熔点_CAS号【121-19-7】_化源网 地址：https://m.chemsrc.com/mip/cas/121-19-7_946693.html