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盐酸匹敌威

盐酸匹敌威用途

Pitofenone hydrochloride 是一种解痉化合物,能够抑制乙酰胆碱酯酶 (AChE) 的活性,对于来自牛红细胞和电鳗的乙酰胆碱酯酶的 Ki 值分别为 36 和 45 μM。

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盐酸匹敌威名称

[ CAS 号 ]:
1248-42-6

[ 中文名 ]:
盐酸匹敌威

[ 英文名 ]:
Pitofenone hydrochloride

[英文别名 ]:

pitofenone hydrochloride

盐酸匹敌威生物活性

[ 描述 ]:

Pitofenone hydrochloride 是一种解痉化合物,能够抑制乙酰胆碱酯酶 (AChE) 的活性,对于来自牛红细胞和电鳗的乙酰胆碱酯酶的 Ki 值分别为 36 和 45 μM。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 疼痛

研究领域 >> 神经疾病

[ 靶点 ]

Ki: 36 μM (AChE, bovine erythrocytes), 45 μM (AChE, electric eel)

[参考文献]

[1]. Punekar NS, et al. Acetylcholinesterase inhibition by pitofenone: a spasmolytic compound. Biotechnol Appl Biochem. 1991 Dec;14(3):378-82.

[相关活性小分子]

盐酸匹敌威物理化学性质

[ 沸点 ]:
512ºC at 760 mmHg

[ 分子式 ]:
C₂₂H₂₆ClNO₄

[ 分子量 ]:
403.89900

[ 闪点 ]:
263.4ºC

[ 精确质量 ]:
403.15500

[ PSA ]:
55.84000

[ LogP ]:
4.30880

[ 蒸汽压 ]:
1.35E-10mmHg at 25°C

[ 储存条件 ]:
2-8℃

盐酸匹敌威毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH6477800

CHEMICAL NAME :: Benzoic acid, o-(p-(2-piperidinoethoxy)benzoyl)-, methyl ester, hydrochloride

CAS REGISTRY NUMBER :: 1248-42-6

LAST UPDATED :: 198912

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C22-H25-N-O4.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 690 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985

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盐酸匹敌威安全信息

[ 海关编码 ]:
2933399090

盐酸匹敌威海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%