(S)-10-Hydroxycamptothecin-d5

(S)-10-Hydroxycamptothecin-d5用途

(S) -10-羟基喜树碱-d5(10-HCPT-d5)是氘标记的(S)-10-羟基喜树碱。(S) -10-羟基喜树碱(10-HCPT)是一种DNA拓扑异构酶I抑制剂。(S) -10-羟基喜树碱具有显著的凋亡诱导作用。(S) -10-羟基喜树碱有可能用于肝癌、胃癌、结肠癌和白血病研究[1][2][3][4]。

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(S)-10-Hydroxycamptothecin-d5名称

[ CAS 号 ]:
1330277-66-1

[ 中文名 ]:
(S)-10-羟基喜树碱 d5

[ 英文名 ]:
(S)-10-Hydroxycamptothecin-d5

(S)-10-Hydroxycamptothecin-d5生物活性

[ 描述 ]:

(S) -10-羟基喜树碱-d5(10-HCPT-d5)是氘标记的(S)-10-羟基喜树碱。(S) -10-羟基喜树碱(10-HCPT)是一种DNA拓扑异构酶I抑制剂。(S) -10-羟基喜树碱具有显著的凋亡诱导作用。(S) -10-羟基喜树碱有可能用于肝癌、胃癌、结肠癌和白血病研究[1][2][3][4]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶

[体外研究]

氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecinwith targeted nanostructured lipid carriers againstmultidrug resistance. Journal of Drug Targeting.

[3]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targetednanostructured lipid carriers against multidrug resistance. J Drug Target, Early Online: 1–8

[4]. Yu P, et al. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biol Pharm Bull. 2012;35(8):1295-9.

[5]. Zhang XW, et al. Differentiation-inducing action of 10-hydroxycamptothecin on human hepatoma Hep G2 cells. Acta Pharmacol Sin. 2000 Apr;21(4):364-8.

[6]. Zhang XW, et al. Differential regulation of P53, c-Myc, Bcl-2, Bax and AFP protein expression, and caspase activity during 10-hydroxycamptothecin-induced apoptosis in Hep G2 cells. Anticancer Drugs. 2000 Oct;11(9):747-56.

[7]. Liu M, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target. 2016;24(5):433-40.

(S)-10-Hydroxycamptothecin-d5物理化学性质

[ 分子式 ]:
C₂₀H₁₁D₅N₂O₅

[ 分子量 ]:
369.38

[ 储存条件 ]:
-20°C，干燥，密封

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相关化合物

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标题：【(S)-10-Hydroxycamptothecin-d5】(S)-10-Hydroxycamptothecin-d5 CAS号:1330277-66-1【结构式性质活性】-化源网地址：https://m.chemsrc.com/mip/cas/1330277-66-1_1681564.html