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月桂酸甘油酯

月桂酸甘油酯用途

单月桂苷(1-Monolaurin)具有抗病毒和抗菌活性[1][2]。

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月桂酸甘油酯名称

[ CAS 号 ]:
142-18-7

[ 中文名 ]:
月桂酸甘油酯

[ 英文名 ]:
UNII:WR963Y5QYW

[中文别名 ]:

[英文别名 ]:

Glycerol α-Monolaurate
MFCD00037815
2,3-Dihydroxypropyl laurate
EINECS 205-526-6
Dodecanoic acid, 2,3-dihydroxypropyl ester
1-Lauroyl-rac-glycerol
UNII:WR963Y5QYW
2,3-Dihydroxypropyl dodecanoate
Monolaurin

月桂酸甘油酯生物活性

[ 描述 ]:

单月桂苷(1-Monolaurin)具有抗病毒和抗菌活性[1][2]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> SARS冠状病毒

研究领域 >> 炎症/免疫

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Harry G Preuss, et al. Minimum inhibitory concentrations of herbal essential oils and monolaurin for gram-positive and gram-negative bacteria. Mol Cell Biochem. 2005 Apr;272(1-2):29-34.

[2]. Edy Subroto, et al. Bioactive monolaurin as an antimicrobial and its potential to improve the immune system and against COVID-19: a review. Food Research 4(6):2355-2365.

月桂酸甘油酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
397.4±22.0 °C at 760 mmHg

[ 熔点 ]:
63ºC

[ 分子式 ]:
C₁₅H₃₀O₄

[ 分子量 ]:
274.396

[ 闪点 ]:
135.6±15.8 °C

[ 精确质量 ]:
274.214417

[ PSA ]:
66.76000

[ LogP ]:
4.04

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.467

[ 储存条件 ]:
−20°C

月桂酸甘油酯MSDS

详细MSDS(安全技术说明书)

月桂酸甘油酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OF1600000

CHEMICAL NAME :: Laurin, 1-mono-

CAS REGISTRY NUMBER :: 142-18-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H30-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 53400 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 21,348,1956 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83109 No. of Facilities: 862 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 7664 (estimated)

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月桂酸甘油酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
OF1600000

月桂酸甘油酯文献

Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.

Antimicrob. Agents Chemother. 53 , 1898-906, (2009)

Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have sho...

Mometasone furoate-loaded cold processed oil-in-water emulsions: in vitro and in vivo studies.

Drug Deliv. 22 , 562-72, (2015)

Over the years, research has focused on strategies to increase benefit/risk ratio of corticoids. However, vehicles intended for topical glucocorticoids delivery with an improved benefit/risk ratio are...

Characterization and antimicrobial activity of a pharmaceutical microemulsion.

Int. J. Pharm. 395 , 154-160, (2010)

The characterization of a pharmaceutical microemulsion system with glycerol monolaurate as oil, ethanol as cosurfactant, Tween 40 as surfactant, sodium diacetate and water, and the antimicrobial activ...

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