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阿德福韦酯

阿德福韦酯用途

Adefovir Dipivoxil可阻断HBV逆转录酶。

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阿德福韦酯名称

[ CAS 号 ]:
142340-99-6

[ 中文名 ]:
阿德福韦酯

[ 英文名 ]:
Adefovir Dipivoxil

[中文别名 ]:

[英文别名 ]:

BIS POM PMEA
ADEFOVIR PIVOXIL
Adefovir Dipivoxil
Hepsera
ADEFOVIR DIPVOXIL
Preveon
MFCD00869897
EINECS 200-001-8
ADEFOVIR DIPIVOLIX
Adefovir Dipivoxyl

阿德福韦酯生物活性

[ 描述 ]:

Adefovir Dipivoxil可阻断HBV逆转录酶。

[ 相关类别 ]:

信号通路 >> 抗感染 >> HBV

信号通路 >> 抗感染 >> 逆转录酶

研究领域 >> 感染

[参考文献]

[1]. Marcellin, P., et al., Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med, 2003. 348(9): p. 808-16.

[2]. Manolakopoulos, S., et al., Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine. Aliment Pharmacol Ther, 2008. 27(3): p. 266-73.

[3]. Committee, A.I.S., A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection: the ADHOC trial. HIV Med, 2002. 3(4): p. 229-38.

[4]. Fisher, E.J., et al., The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial. AIDS, 2001. 15(13): p. 1695-700.

[相关活性小分子]

阿德福韦酯物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
641.0±65.0 °C at 760 mmHg

[ 熔点 ]:
98-102ºC

[ 分子式 ]:
C₂₀H₃₂N₅O₈P

[ 分子量 ]:
501.470

[ 闪点 ]:
341.5±34.3 °C

[ 精确质量 ]:
501.198853

[ PSA ]:
176.79000

[ LogP ]:
2.45

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.569

[ 储存条件 ]:
−20°C

阿德福韦酯MSDS

阿德福韦酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

阿德福韦酯合成路线

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阿德福韦酯文献

Modulating the dehydration conditions of adefovir dipivoxil dihydrate to obtain different physical forms of anhydrate.

J. Pharm. Sci. 104(3) , 1056-64, (2015)

The physical form of anhydrous adefovir dipivoxil (AD), obtained following the dehydration of AD dihydrate, was governed by the kinetics of water removal. The rate and extent of water removal followin...

De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis.

World J. Gastroenterol. 19(37) , 6278-83, (2013)

To compare efficacy of combined lamivudine (LAM) and adefovir dipivoxil (ADV) therapy with that of entecavir (ETV) monotherapy for hepatitis B virus (HBV)-related decompensated liver cirrhosis.A total...

Discovering novel direct acting antiviral agents for HBV using in silico screening.

Biochem. Biophys. Res. Commun. 456(1) , 20-8, (2015)

The treatments for chronic hepatitis B (CHB) are interferon and nucleoside analogues reverse transcriptase (RT) inhibitors. Because both treatments are less than ideal, we conducted to identify novel ...

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阿德福韦酯

阿德福韦酯用途

阿德福韦酯名称

阿德福韦酯生物活性

阿德福韦酯物理化学性质

阿德福韦酯MSDS

详细MSDS(安全技术说明书)

阿德福韦酯安全信息

阿德福韦酯合成路线

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阿德福韦酯文献

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