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米格列奈钙

米格列奈钙用途

【用途一】
为全合成的抗Ⅱ型糖尿病新药

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米格列奈钙名称

[ CAS 号 ]:
145525-41-3

[ 中文名 ]:
米格列奈钙

[ 英文名 ]:
Mitiglinide (Calcium)

[中文别名 ]:

米格列奈

[英文别名 ]:

Mitiglinide
Mitiglinide calcium
MFCD08458378
Mitiglinide hemicalcium salt
Mitiglinide (Calcium)

米格列奈钙生物活性

[ 描述 ]:

Mitiglinide(KAD-1229; S21403)是KATP通道拮抗剂,具有抗2型糖尿病活性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钾通道

研究领域 >> 代谢疾病

[参考文献]

[1]. Kiyoshi Ichikawa, Tokuhisa Yamato, Kazuma Ojima, et al. Effect Of Kad-1229, A Novel Hypoglycaemic Agent, On Plasma Glucose Levels After Meal Load In Type 2 Diabetic Rats. Clinical and Experimental Pharmacology and Physiology. 2002, 29 (5-6): 423-427

[2]. Sunaga Y, Gonoi T, Shibasaki T, et al. The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.European Journal of Pharmacology.2001, 431(1):119

[3]. Kiyoshi Ichikawa, Kazuyasu Maruyama, Makoto Murakami, et al. Absence of exacerbation of myocardial stunning in anesthetized dogs treated with KAD-1229, a novel hypoglycemic agent. European Journal of Pharmacology.2001, 3(23): 331-338

[4]. Ohnota H, Kitamura T, Kinukawa M, et al. A rapid- and short-acting hypoglycemic agent KAD-1229 improves post-prandial hyperglycemia and diabetic complications in streptozotocin-induced non-insulin-dependent diabetes mellitus rats. Japanese Journal of Phar

[5]. Hideo Mogamia, Hiroshi Shibataa, Romi Nobusawaa, et al. Inhibition of ATP-sensitive K+ channel by a non-sulfonylurea compound KAD-1229 in a pancreatic β-cell line, MIN 6 cell.. European Journal of Pharmacology: Molecular Pharmacology. 1994, 269(3): 293-29

[相关活性小分子]

米格列奈钙物理化学性质

[ 密度 ]:
1.175

[ 沸点 ]:
519.6ºC at 760 mmHg

[ 熔点 ]:
146-148ºC

[ 分子式 ]:
C₁₉H₂₄NO₃Ca_0.5

[ 分子量 ]:
334.44

[ 闪点 ]:
268ºC

[ PSA ]:
102.45000

[ LogP ]:
5.59450

[ 外观性状 ]:
白色晶体粉末

[ 蒸汽压 ]:
1.27E-11mmHg at 25°C

[ 储存条件 ]:
room temp

米格列奈钙安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2942000000

米格列奈钙海关

[ 海关编码 ]: 2942000000

米格列奈钙文献

Efficacy and safety of mitiglinide versus nateglinide in newly diagnose patients with type 2 diabetes mellitus: a randomized double blind trial.

Diabetes Obes. Metab. 14(2) , 187-9, (2012)

This study was performed to examine the efficacy and safety of mitiglinide in type 2 diabetes patients (T2DM). Enrolled patients had received treatment with diet and exercise in the previous 3 months ...

Comparison of the rapidity of onset of the therapeutic effect between nateglinide and mitiglinide by PK/PD analysis in rats.

Eur. J. Drug Metab. Pharmacokinet. 37(1) , 9-15, (2012)

Nateglinide and mitiglinide are immediate short-acting insulinotropic agents. Both are administered preprandially to control postprandial hyperglycemia. Glinide drugs are characterized by immediate on...

Variations in tissue selectivity amongst insulin secretagogues: a systematic review.

Diabetes Obes. Metab. 14(2) , 130-8, (2012)

Insulin secretagogues promote insulin release by binding to sulfonylurea receptors on pancreatic β-cells (SUR1). However, these drugs also bind to receptor isoforms on cardiac myocytes (SUR2A) and vas...

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米格列奈钙

米格列奈钙用途

米格列奈钙名称

米格列奈钙生物活性

米格列奈钙物理化学性质

米格列奈钙安全信息

米格列奈钙海关

米格列奈钙文献

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