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醋酸西曲瑞克

醋酸西曲瑞克用途

Cetrorelix Acetate是 GnRH 受体的强效拮抗剂,其 IC50 值为 1.21 nM.

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醋酸西曲瑞克名称

[ CAS 号 ]:
145672-81-7

[ 中文名 ]:
醋酸西曲瑞克

[ 英文名 ]:
Cetrorelix Acetate

醋酸西曲瑞克生物活性

[ 描述 ]:

Cetrorelix Acetate是 GnRH 受体的强效拮抗剂,其 IC50 值为 1.21 nM.

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> GNRH受体

研究领域 >> 神经疾病

多肽产品

[ 靶点 ]

IC50: 1.21 nM GnRH[1].

[体外研究]

Cetrorelix Acetate以1000ng/ml抑制ES-2细胞系的生长。 Cetrorelix Acetate具有与GnRH-I激动剂相当的抗增殖作用,表明GnRH-I激动剂和拮抗剂的二分法可能不适用于癌细胞中的GnRH-I系统[2]。

[参考文献]

[1]. Beckers T et al. Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal Biochem. 1997 Aug 15;251(1):17-23.

[2]. Gründker C et al. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod Biol Endocrinol. 2003 Oct 7;1:65.

[相关活性小分子]

醋酸西曲瑞克物理化学性质

[ 分子式 ]:
C₇₂H₉₆ClN₁₇O₁₆

[ 分子量 ]:
1491.09000

[ 精确质量 ]:
1489.69000

[ PSA ]:
532.97000

[ LogP ]:
6.02320

[ 储存条件 ]:
-20°C

醋酸西曲瑞克安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H361

[ 警示性声明 ]:
P281

[ 危险品运输编码 ]:
NONH for all modes of transport

醋酸西曲瑞克文献

Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency.

Hum. Reprod. 30(3) , 608-15, (2015)

Is ovarian tissue cryopreservation using vitrification followed by in vitro activation (IVA) of dormant follicles a potential approach for infertility treatment of patients with primary ovarian insuff...

Ovarian stimulation and in-vitro fertilization outcomes of cancer patients undergoing fertility preservation compared to age matched controls: a 17-year experience.

J. Assist. Reprod. Genet. 32(4) , 587-96, (2015)

To compare the in-vitro fertilization (IVF) outcomes of cancer patients who underwent oocyte retrieval and embryo/oocyte cryopreservation prior to gonadotoxic therapy to those of age and time-matched ...

Sperm morphological normality under high magnification predicts laboratory and clinical outcomes in couples undergoing ICSI.

Hum. Fertil. (Camb.) 18 , 81-6, (2015)

The objective of this study was to evaluate whether 'motile sperm organelle morphology examination' (MSOME) is correlated with the outcome of ICSI. A total of 14400 spermatozoa from 72 couples undergo...

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