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德舍瑞林

德舍瑞林用途

Deslorelin是GnRH的激动剂。
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德舍瑞林名称

[ CAS 号 ]:
57773-65-6

[ 中文名 ]:
地洛瑞林

[ 英文名 ]:
Deslorelin

[中文别名 ]:

[英文别名 ]:

德舍瑞林生物活性

[ 描述 ]:

Deslorelin是GnRH的激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> GNRH受体
多肽产品
研究领域 >> 其他

[参考文献]

[1]. Lucas X. Clinical use of deslorelin (GnRH agonist) in companion animals: a review. Reprod Domest Anim. 2014 Oct;

[2]. Bujok J et al. Influence of ovariohysterectomy and deslorelin acetate on the spontaneous activity of the rabbit urinary bladder in vitro. Theriogenology. 2016 Feb;85(3):441-6.


[相关活性小分子]

醋酸亮丙瑞林 | 阿拉瑞林 | 醋酸西曲瑞克 | 曲普瑞林 | 醋酸戈舍瑞林 | 醋酸布舍瑞林 | 恶拉戈利 | 瑞卢戈利 | 那法瑞林 | 醋酸戈那瑞林 | 醋酸兰瑞肽 | opigolix

德舍瑞林物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
1783.4ºC at 760 mmHg

[ 分子式 ]:
C64H83N17O12

[ 分子量 ]:
1282.450

[ 闪点 ]:
1032.4ºC

[ 精确质量 ]:
1281.640747

[ PSA ]:
444.83000

[ LogP ]:
0.77

[ 外观性状 ]:
白色粉末或近乎于白色粉末

[ 折射率 ]:
1.710

[ 储存条件 ]:
−20°C

德舍瑞林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OK6755000
CHEMICAL NAME :
Luteinizing hormone-releasing factor (pig), 6-D-tryptophan-9-(N-ethyl-L-prolinamide)-10- deglycinamide-
CAS REGISTRY NUMBER :
57773-65-6
LAST UPDATED :
199706
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C64-H83-N17-O12
MOLECULAR WEIGHT :
1282.64

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
30 ug/kg
SEX/DURATION :
male 42 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - impotence Reproductive - Paternal Effects - other effects on male
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 305,663,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Fertility - other measures of fertility
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 135,759,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Fertility - other measures of fertility
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 37,209,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
2 ug/kg
SEX/DURATION :
female 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - other measures of fertility
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 205,408,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
28 ng/kg
SEX/DURATION :
male 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 105,1191,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
40 ug/kg
SEX/DURATION :
male 9 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male Endocrine - changes in luteinizing hormone Endocrine - androgenic
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 35,79,1987
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
70 ug/kg
SEX/DURATION :
female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1545,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
25 ug/kg
SEX/DURATION :
female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 110,347,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
35 ug/kg
SEX/DURATION :
female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 103,2299,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
15 ug/kg
SEX/DURATION :
female 5-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 103,2299,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
25 ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
44LVAU "Peptides' Structure and Biological Function, Proceedings of the American Peptide Symposium, 6th, 1979," Cross, E. and J. Meienhofer, eds., Rockford, IL, Pierce Chemical Co., 1979 Volume(issue)/page/year: 6,781,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
150 ug/kg
SEX/DURATION :
female 75 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 25,171,1980
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德舍瑞林安全信息

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R60

[ 安全声明 (欧洲) ]:
53-22-36/37/39-45

[ WGK德国 ]:
3

[ RTECS号 ]:
OK6755000

德舍瑞林制备

【方法一】
以相应的保护氨基酸单体为原料，通过固相或液相合成法合成制得。
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相关化工产品/化学物质：

推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：德舍瑞林

公司名：吉尔生化（上海）有限公司

区域：上海市闵行区

价格：
$需询单/1kg

联系人：杨经理

产品详情：Deslorelin Acetate

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥2599.9/50mg ￥3999.9/100mg ￥859.9/10mg ￥6399.9/200mg

联系人：阿拉丁

产品详情：醋酸德舍瑞林

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥1742.0/5mg

联系人：夏言

产品详情：[Perfemiker]Deslorelin,>99%

公司名：武汉鼎信通药业有限公司

区域：武汉市江夏区

价格：
￥需询单/1kg ￥需询单/10kg ￥需询单/50kg ￥需询单/500kg

联系人：董浩

产品详情：德舍瑞林

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