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醋硝香豆素

醋硝香豆素用途

Acenocoumarol是一种抗凝血剂,功能如同一个Vitamin K拮抗剂。
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醋硝香豆素名称

[ CAS 号 ]:
152-72-7

[ 中文名 ]:
醋硝香豆素

[ 英文名 ]:
acenocoumarol

[中文别名 ]:

[英文别名 ]:

醋硝香豆素生物活性

[ 描述 ]:

Acenocoumarol是一种抗凝血剂,功能如同一个Vitamin K拮抗剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 心血管疾病

[相关活性小分子]

磺丁基-β-环糊精钠盐 | 环孢霉素A | 2-(3,6-二乙酰氧基-2,7-二氯-9H-氧杂蒽-9-基)苯甲酸 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | GW4869 | 乙莫克舍 | (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫代双(4-(4-(3-氟苯基)-1H-1,-1H-1,2,3-三唑-1-基)-2-(羟甲基)四氢-2H-吡喃-3,5-二醇) | Mitoquinone甲磺酸盐 | GSK2795039 | CBIC2 | BAPTA-AM | AP20187 | GKT137831 | D-(-)-荧光素 | 单响尾蛇毒蛋白

醋硝香豆素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
592.7±50.0 °C at 760 mmHg

[ 熔点 ]:
196-199ºC

[ 分子式 ]:
C19H15NO6

[ 分子量 ]:
353.326

[ 闪点 ]:
312.3±30.1 °C

[ 精确质量 ]:
353.089935

[ PSA ]:
113.33000

[ LogP ]:
3.15

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.656

[ 储存条件 ]:
库房通风低温干燥,与食品添加剂分开存放

[ 水溶解性 ]:
DMSO, heptane and xylene: ≥17mg/mL

醋硝香豆素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN4900000
CHEMICAL NAME :
Coumarin, 3-(alpha-acetonyl-p-nitrobenzyl)-4-hydroxy-
CAS REGISTRY NUMBER :
152-72-7
LAST UPDATED :
199504
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C19-H15-N-O6
MOLECULAR WEIGHT :
353.35
WISWESSER LINE NOTATION :
T66 BOVJ DY1V1&R DNW& EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
513 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,3,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 11,85,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
115 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,6,1989 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
24 mg/kg
SEX/DURATION :
female 1-28 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
AFPEAM Archives Francaises de Pediatrie. (Doin Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1942- Volume(issue)/page/year: 36,63,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7380 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 239 (estimated) No. of Female Employees: 157 (estimated)
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醋硝香豆素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P301 + P312 + P330-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
63-22-36/37/38

[ 安全声明 (欧洲) ]:
26-36/37

[ 危险品运输编码 ]:
UN 2811

[ RTECS号 ]:
GN4900000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2932209090

醋硝香豆素合成路线

详细合成路线

醋硝香豆素上下游产品

醋硝香豆素上游产品

醋硝香豆素下游产品

醋硝香豆素制备

将4-羟基香豆素和4-对硝基苯基丁烯-3-酮进行加成反应，得到的新抗凝粗品用丙酮重结晶，总收率55%。

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醋硝香豆素海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

醋硝香豆素文献

A chiral separation strategy for acidic drugs in capillary electrochromatography using both chlorinated and nonchlorinated polysaccharide-based selectors.

Electrophoresis 35(19) , 2807-18, (2014)

A generic chiral separation strategy for the analysis of acidic compounds in CEC is proposed in completion of an earlier defined strategy for nonacidic compounds. The screening step of this strategy u...

A rapid method for determination of 22 selected drugs in human urine by UHPLC/MS/MS for clinical application.

J. AOAC Int. 97(6) , 1526-37, (2015)

A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs we...

Prophylaxis of experimental endocarditis with antiplatelet and antithrombin agents: a role for long-term prevention of infective endocarditis in humans?

J. Infect. Dis. 211(1) , 72-9, (2014)

Infective endocarditis (IE) mostly occurs after spontaneous low-grade bacteremia. Thus, IE cannot be prevented by circumstantial antibiotic prophylaxis. Platelet activation following bacterial-fibrino...


更多文献

推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：新抗凝

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Sintrom

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥2628.0/50mg ￥574.0/10mg ￥4669.0/100mg ￥1380.0/100mg

联系人：李先生

产品详情：Acenocoumarol

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥476.9/25mg ￥115.9/5mg ￥978.9/100mg ￥需询单/1g

联系人：阿拉丁

产品详情：乙酰香豆酚

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥261.0/5mg ￥887.0/25mg ￥2586.22/50mg ￥573.3/10mg

联系人：夏言

产品详情：[Perfemiker]醋硝香豆素,>98.0%(HPLC)

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相关化合物

【醋硝香豆素】化源网提供醋硝香豆素CAS号152-72-7，醋硝香豆素MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询醋硝香豆素上化源网，专业又轻松。>>电脑版：醋硝香豆素

标题：醋硝香豆素_用途_密度_熔点_醋硝香豆素CAS号【152-72-7】_化源网 地址：https://m.chemsrc.com/mip/cas/152-72-7_826550.html