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焦磷酸硫胺素

焦磷酸硫胺素用途

Thiamine pyrophosphate 是维生素 B1 的辅酶形式,是丙酮酸脱氢酶复合物和酮戊二酸脱氢酶复合物的必需中间体。
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焦磷酸硫胺素名称

[ CAS 号 ]:
154-87-0

[ 中文名 ]:
焦磷酸硫胺素

[ 英文名 ]:
Cocarboxylase

[中文别名 ]:

[英文别名 ]:

焦磷酸硫胺素生物活性

[ 描述 ]:

Thiamine pyrophosphate 是维生素 B1 的辅酶形式,是丙酮酸脱氢酶复合物和酮戊二酸脱氢酶复合物的必需中间体。

[ 相关类别 ]:

天然产物 >> 其他
研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite


[相关活性小分子]

3-甲基腺嘌呤 | 氢化可的松 | N-乙酰半胱氨酸 | 维生素A酸； 视黄酸 | 褪黑素 | 地诺前列酮 | 烟酰胺 | 5'-三磷酸腺苷 | 对乙酰氨基苯酚 | 列腺素 E1 | 去氢表雄酮 | 肾上腺酮 | 孕酮； 黄体素； 黄体酮 | 二十二碳六烯酸 | 辅酶I

焦磷酸硫胺素物理化学性质

[ 分子式 ]:
C12H19ClN4O7P2S

[ 分子量 ]:
460.767

[ 精确质量 ]:
460.013824

[ PSA ]:
216.83000

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 储存条件 ]:
2-8°C

焦磷酸硫胺素MSDS

详细MSDS(安全技术说明书)

焦磷酸硫胺素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XI7552000
CHEMICAL NAME :
Thiamine, trihydrogen pyrophosphate (ester)
CAS REGISTRY NUMBER :
154-87-0
LAST UPDATED :
199806
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C12-H19-N4-O7-P2-S.Cl
MOLECULAR WEIGHT :
460.80
WISWESSER LINE NOTATION :
T6N CNJ B1 DZ E1- AT5K CSJ D2OPQO&OPQQO E1 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
465 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,1025,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,1025,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3828 No. of Facilities: 172 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 850 (estimated) No. of Female Employees: 766 (estimated)
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焦磷酸硫胺素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
1759

[ WGK德国 ]:
3

[ RTECS号 ]:
XI7552000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

焦磷酸硫胺素合成路线

详细合成路线

焦磷酸硫胺素上下游产品

焦磷酸硫胺素上游产品

焦磷酸硫胺素下游产品

焦磷酸硫胺素制备

【方法一】
盐酸硫胺与磷酸反应，再经盐酸处理制得。
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焦磷酸硫胺素文献

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Biofactors 41 , 232-41, (2015)

Complex regulatory mechanisms control the expression of folate transporters within cells. Liver is the primary reserve of the folate stores within the body. As excessive alcohol consumption or ineffic...

The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy.

Drug Metab. Dispos. 42(10) , 1656-62, (2014)

The clinical development of fedratinib, a Janus kinase (JAK2) inhibitor, was terminated after reports of Wernicke's encephalopathy in myelofibrosis patients. Since Wernicke's encephalopathy is induced...

Gene Transfer Efficiency in Gonococcal Biofilms: Role of Biofilm Age, Architecture, and Pilin Antigenic Variation.

J. Bacteriol. 197 , 2422-31, (2015)

Extracellular DNA is an important structural component of many bacterial biofilms. It is unknown, however, to which extent external DNA is used to transfer genes by means of transformation. Here, we q...


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公司名：上海阿拉丁生化科技股份有限公司

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产品详情：[Perfemiker]焦磷酸硫胺素,98%

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【焦磷酸硫胺素】化源网提供焦磷酸硫胺素CAS号154-87-0，焦磷酸硫胺素MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询焦磷酸硫胺素上化源网，专业又轻松。>>电脑版：焦磷酸硫胺素

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