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Echistatin

Echistatin用途

Echistatin 最初是来自蛇毒崩素家族中最小的 RGD 活性蛋白,是一种有效的血小板聚集的抑制剂。Echistatin 是体外骨吸收的有效抑制剂。Echistatin 是有效的 αIIbβ3、αvβ3 和α5β1 的拮抗剂。

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Echistatin名称

[ CAS 号 ]:
154303-05-6

[ 中文名 ]:
Echistatin,α1 isoform

[ 英文名 ]:
Echistatin

Echistatin生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

研究领域 >> 代谢疾病

信号通路 >> 细胞骨架 >> Integrin

[ 靶点 ]

αvβ3

α5β1

αIIbβ3

[参考文献]

[1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.

[2]. M Sato, et al. Echistatin is a potent inhibitor of bone resorption in culture. J Cell Biol. 1990 Oct;111(4):1713-23.

[3]. C C Kumar, et al. Biochemical characterization of the binding of echistatin to integrin alphavbeta3 receptor. J Pharmacol Exp Ther. 1997 Nov;283(2):843-53.

[4]. I Wierzbicka-Patynowski, et al. Structural requirements of echistatin for the recognition of alpha(v)beta(3) and alpha(5)beta(1) integrins. J Biol Chem. 1999 Dec 31;274(53):37809-14.

Echistatin物理化学性质

[ 分子式 ]:
C₂₁₇H₃₄₁N₇₁O₇₄S₉

[ 分子量 ]:
5417.0

[ 储存条件 ]:
-20°C，干燥，密封

Echistatin安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

Echistatin文献

Biochemical characterization of the binding of echistatin to integrin alphavbeta3 receptor.

J. Pharmacol. Exp. Ther. 283(2) , 843-53, (1997)

Echistatin is a 49-amino-acid peptide belonging to the family of disintegrins that are derived from snake venoms and are potent inhibitors of platelet aggregation and cell adhesion. Integrin alphavbet...

Vitronectin receptor (alpha(v)beta3) mediates platelet adhesion to the luminal aspect of endothelial cells: implications for reperfusion in acute myocardial infarction.

Circulation 96(6) , 1809-18, (1997)

Platelet interaction with endothelium plays an important role in the pathophysiology of coronary microcirculation. We assessed the role of the vitronectin receptor (integrin alpha(v)beta3) in platelet...

Structural analysis of a biologically active echistatin analogue des(46-49)-[Ala8,37]-echistatin gamma with three disulfide bonds by 2D-NMR and computer graphics.

Biochem. Biophys. Res. Commun. 220(2) , 246-54, (1996)

An echistatin analogue, designated as des(46-49)-[Ala8,37]-echistatin gamma, was synthesized chemically by solid-phase peptide synthesis. The analogue was made by replacing Cys8 and Cys37 residues wit...

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