对氨基苯乙醚
对氨基苯乙醚用途
该品用于生产橡胶防老剂AW，即6-乙氧基-2,2,4-三甲基-1,2-二氢化喹啉。也用于饲料和食品，可防止脂肪、蛋白质在贮存过程中氧化变质，还用于维生素A和维生素E等药品的保存。作为饲料和食品抗氧化剂时，称乙氧喹（[91-53-27]）。在医药方面，用于生产解热镇痛药非那西丁、安痨息和消毒防腐药利凡诺。在染料方面，该品是色酚AS-VL、茜素红5G和坚牢酸性蓝R的中间体。
测定铜、铁、锰、钒、锌、铬酸盐和氰化物。氧化还原指示剂。有机合成。染料制造
对氨基苯乙醚名称
[ CAS 号 ]:
156-43-4
[ 中文名 ]:
对乙氧基苯胺
[ 英文名 ]:
2-Phenoxyethanamine
[中文别名 ]:
[英文别名 ]:
- 2-Phenoxyethanamine
- 4-Aminophenetole
- p-Phenetidine
- MFCD00007865
- EINECS 205-855-5
- 2-Phenoxy-ethylamine
- Ethanamine, 2-phenoxy-
- Phenetidine
- 4-Ethoxyaniline
对氨基苯乙醚物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
230.3±23.0 °C at 760 mmHg
[ 熔点 ]:
2-5 °C(lit.)
[ 分子式 ]:
C8H11NO
[ 分子量 ]:
137.179
[ 闪点 ]:
97.9±15.9 °C
[ 精确质量 ]:
137.084061
[ PSA ]:
35.25000
[ LogP ]:
0.89
[ 外观性状 ]:
无色液体
[ 蒸汽压 ]:
0.1±0.5 mmHg at 25°C
[ 折射率 ]:
1.527
[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运
[ 稳定性 ]:
Stability Stable, but light and air sensitive. Combustible. Incompatible with strong oxidizing agents.
[ 水溶解性 ]:
practically insoluble
对氨基苯乙醚MSDS
对氨基苯乙醚毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SI6465500
- CHEMICAL NAME :
- p-Phenetidine
- CAS REGISTRY NUMBER :
- 156-43-4
- BEILSTEIN REFERENCE NO. :
- 0606666
- LAST UPDATED :
- 199807
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C8-H11-N-O
- MOLECULAR WEIGHT :
- 137.20
- WISWESSER LINE NOTATION :
- ZR DO2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Rinsed with water
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 540 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 487 mg/m3/4H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 530 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 692 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 7 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2353 mg/kg
- TOXIC EFFECTS :
- Cardiac - other changes Lungs, Thorax, or Respiration - emphysema Kidney, Ureter, Bladder - hematuria
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1120 mg/kg/28D-I
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15250 ug/kg/9W-I
- TOXIC EFFECTS :
- Blood - normocytic anemia Blood - methemoglobinemia-carboxyhemoglobin Blood - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 45750 ug/kg/9W-I
- TOXIC EFFECTS :
- Blood - normocytic anemia Blood - methemoglobinemia-carboxyhemoglobin Blood - other changes
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 160 umol/L
- REFERENCE :
- MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,51,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4375 No. of Facilities: 6 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 206 (estimated) No. of Female Employees: 23 (estimated)
对氨基苯乙醚安全信息
[ 符号 ]:
GHS06, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H302-H311-H319-H332-H334
[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P342 + P311
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
T:Toxic;Xn:Harmful;
[ 风险声明 (欧洲) ]:
R20/21/22;R23/24/25;R33;R36;R43;R68
[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S46
[ 危险品运输编码 ]:
UN 2311 6.1/PG 3
[ WGK德国 ]:
1
[ RTECS号 ]:
SI6465500
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1
[ 海关编码 ]:
29222200
对氨基苯乙醚合成路线
对氨基苯乙醚上下游产品
对氨基苯乙醚上游产品
对氨基苯乙醚下游产品
对氨基苯乙醚制备
1.由对硝基苯乙醚（[100-29-8]）还原而得。将硫化钠、硫磺加水升温至138-142℃，溶液静置澄清后加入还原锅内。加热搅拌，于5-6.5h内均匀缓慢加完对硝基苯乙醚，在132-134℃常压反应3h，在138-140℃加压（0.1MPa以下）反应10-12h。加水搅拌后静置1h。分去下层硫代硫酸钠母液，上层油层分净残渣，减压蒸馏，收集168-170℃（5.33kPa）馏分，得含量99%的对乙氧基苯胺。收率95%以上。也可采用加氢还原，以镍作催化剂，在130-140℃，0.6MPa压力下通氢反应，对硝基苯乙醚还原为对乙氧基苯胺。另外，以硝基苯为原料，在硫酸存在下，采用氧化镍为催化剂，二甲亚砜为促进剂，与无水乙醇乙氧基化，并还原一步制得对乙氧基苯胺。
2.对氨基苯酚法 经与氯乙烷反应制得。
对氨基苯乙醚海关
[ 海关编码 ]: 2922291000
[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
[ Summary ]:
2922291000 4-methoxyaniline。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:30.0%
对氨基苯乙醚文献
Gen. Physiol. Biophys. 33(4) , 393-401, (2014)
The effects of nitroglycerin (glyceryl trinitrate - GTN) are mediated by liberated nitric oxide (NO) and formed reactive nitrogen species, which induces oxidative stress during biotransformation in re...
Magnetic beads as an extraction medium for simultaneous quantification of acetaminophen and structurally related compounds in human serum.Drug Test. Anal. 7 , 457-66, (2015)
This paper describes a sample preparation method that complements a previously published liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for acetaminophen and eight structurally-relate...
Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia.Biochem. Pharmacol. 84(9) , 1196-206, (2012)
Phenacetin has been used as an analgesic antipyretic but has now been withdrawn from the market due to adverse effects such as methemoglobinemia and renal failure. It has been suggested that metabolic...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：对乙氧基苯胺
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥88.0/100g
￥238.0/500g
联系人：刘佳
产品详情：对乙氧基苯胺
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥186.0/500g
￥39.0/25g
￥需询单/1g
￥61.0/100g
联系人：阿拉丁
产品详情：对乙氧基苯胺
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相关化合物
【对氨基苯乙醚】化源网提供对氨基苯乙醚CAS号156-43-4，对氨基苯乙醚MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询对氨基苯乙醚上化源网，专业又轻松。>>电脑版：对氨基苯乙醚
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