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4-乙氧基亚甲基-2-苯基恶唑啉-5-酮

4-乙氧基亚甲基-2-苯基恶唑啉-5-酮用途

恶唑酮是一种诱导急性或慢性大肠炎症的半抗原剂,用于构建结肠炎模型。恶唑酮可引起Th1/Th2依赖性结肠炎,伴有体重减轻和腹泻。恶唑酮诱导的炎症可以通过中和抗IL-4或抗TNF-α抗体或诱饵IL-13R2-α-FC蛋白来减轻[1]。

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4-乙氧基亚甲基-2-苯基恶唑啉-5-酮名称

[ CAS 号 ]:
15646-46-5

[ 中文名 ]:
4-乙氧基亚甲基-2-苯基恶唑啉-5-酮

[ 英文名 ]:
4-ethoxymethylene-2-phenyl-2-oxazolin-5-one

[中文别名 ]:

[英文别名 ]:

4-Ethoxymethylene-2-phenyloxazolin-5-one
EINECS 239-713-9
4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE
MFCD00003204
4-(ethoxymethylidene)-2-phenyl-1,3-oxazol-5-one

4-乙氧基亚甲基-2-苯基恶唑啉-5-酮生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 白细胞介素相关

研究领域 >> 炎症/免疫

[ 靶点 ]

IL-4

IL-13

TNFR1

[体内研究]

结肠炎诱导[1] 1。准备流程敏化液的配制(一)：通过涡旋以 4:1 v/v比例混合丙酮和橄榄油。将 60毫克恶唑酮粉末溶解在 2毫升该溶液中,得到 3%(w/v)恶唑酮敏化溶液。小心涡旋混合溶液。挑战液的制备(二)：将 20毫克恶唑酮溶解在 2 mL 50%乙醇中,得到 1%(w/v)溶液。小心涡旋混合溶液。使用前应将恶唑酮粉末完全溶解。 2.实验流程敏化预处理：电剪刀在小鼠背部皮肤上刮去约 2厘米x 2厘米的面积。小心避免开放性伤口。将 150μL恶唑酮致敏液 (I)涂于小鼠裸露皮肤上。请注意使用不含恶唑酮的敏化剂作为对照。诱导处理：腹腔注射氯胺酮/噻嗪溶液(80μ或用异氟烷麻醉系统吸入麻醉小鼠。将导管插入小鼠的结肠 (肛门近端约 3-4厘米深)。导管的另一端连接至 1毫升注射器。将约 100μL恶唑酮刺激液 (II)通过导管注入结肠腔10至30秒。给药后,将鼠标保持垂直位置(头朝下)60秒。

[参考文献]

[1]. Weigmann B, et al. Oxazolone-Induced Colitis as a Model of Th2 Immune Responses in the Intestinal Mucosa. Methods Mol Biol. 2016;1422:253-61.

4-乙氧基亚甲基-2-苯基恶唑啉-5-酮物理化学性质

[ 密度 ]:
1.18 g/cm3

[ 沸点 ]:
308.8ºC at 760 mmHg

[ 熔点 ]:
94-96 °C (dec.)(lit.)

[ 分子式 ]:
C₁₂H₁₁NO₃

[ 分子量 ]:
217.22

[ 闪点 ]:
136.8ºC

[ 精确质量 ]:
217.07400

[ PSA ]:
47.89000

[ LogP ]:
1.30350

[ 外观性状 ]:
白色至橙色至黄褐色的粉末和/或大块

[ 蒸汽压 ]:
0.000666mmHg at 25°C

[ 折射率 ]:
1.561

[ 储存条件 ]:
2-8°C

4-乙氧基亚甲基-2-苯基恶唑啉-5-酮MSDS

详细MSDS(安全技术说明书)

4-乙氧基亚甲基-2-苯基恶唑啉-5-酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ5786250

CHEMICAL NAME :: 2-Oxazolin-5-one, 4-ethoxymethylene-2-phenyl-

CAS REGISTRY NUMBER :: 15646-46-5

LAST UPDATED :: 198209

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H11-N-O3

MOLECULAR WEIGHT :: 217.24

WISWESSER LINE NOTATION :: T5NYVOJ BU1O2 ER

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#06780

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4-乙氧基亚甲基-2-苯基恶唑啉-5-酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R43

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
RQ5786250

[ 海关编码 ]:
2934999090

4-乙氧基亚甲基-2-苯基恶唑啉-5-酮合成路线

详细合成路线

4-乙氧基亚甲基-2-苯基恶唑啉-5-酮上下游产品

4-乙氧基亚甲基-2-苯基恶唑啉-5-酮上游产品

4-乙氧基亚甲基-2-苯基恶唑啉-5-酮下游产品

4-乙氧基亚甲基-2-苯基恶唑啉-5-酮海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-乙氧基亚甲基-2-苯基恶唑啉-5-酮文献

Skin sensitization induced Langerhans' cell mobilization: variable requirements for tumour necrosis factor-α.

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Upon antigen/allergen recognition, epidermal Langerhans' cells (LC) are mobilized and migrate to the local lymph node where they play a major role in initiating or regulating immune responses. It had ...

Paradoxical benefits of psychological stress in inflammatory dermatoses models are glucocorticoid mediated.

J. Invest. Dermatol. 134(12) , 2890-7, (2014)

Acute psychological stress (PS) mobilizes metabolic responses that are of immediate benefit to the host, but the current medical paradigm holds that PS exacerbates systemic and cutaneous inflammatory ...

UVA irradiation of the eye modulates the contact hypersensitivity of the skin and intestines by affecting mast cells in mice.

Photodermatol. Photoimmunol. Photomed. 31(3) , 129-40, (2015)

Ultraviolet A (UVA) irradiation before allergic sensitization induces immunosuppression, but the precise mechanism remained unclear. In this study, we examined the influence of UVA irradiation of the ...

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