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2-氨基-3-甲基吡啶

2-氨基-3-甲基吡啶用途

1.有机合成。

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2-氨基-3-甲基吡啶名称

[ CAS 号 ]:
1603-40-3

[ 中文名 ]:
2-氨基-3-甲基吡啶

[ 英文名 ]:
3-Methylpyridin-2-amine

[中文别名 ]:

[英文别名 ]:

MFCD00006320
3-methylpyridin-2-amine
2-Pyridinamine, 3-methyl-
2-Amino-3-picoline
3-Methyl-2-pyridinamine
3-Methylpyridin-2-amin
EINECS 216-501-4
2-Amino-3-methylpyridine

2-氨基-3-甲基吡啶物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
220.9±20.0 °C at 760 mmHg

[ 熔点 ]:
29-31 °C(lit.)

[ 分子式 ]:
C₆H₈N₂

[ 分子量 ]:
108.141

[ 闪点 ]:
111.7±0.0 °C

[ 精确质量 ]:
108.068748

[ PSA ]:
38.91000

[ LogP ]:
1.08

[ 外观性状 ]:
透明黄色液体在熔点后

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.574

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
SOLUBLE

2-氨基-3-甲基吡啶MSDS

2-氨基-3-甲基吡啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US1850000

CHEMICAL NAME :: Pyridine, 2-amino-3-methyl-

CAS REGISTRY NUMBER :: 1603-40-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H8-N2

MOLECULAR WEIGHT :: 108.16

WISWESSER LINE NOTATION :: T6NJ BZ C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 650 ppm/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 36,491,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01585

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

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2-氨基-3-甲基吡啶安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H331-H373

[ 警示性声明 ]:
P261-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R25;R36/37/38

[ 安全声明 (欧洲) ]:
S36/37/39-S45-S37/39-S28A-S26

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
US1850000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29333999

2-氨基-3-甲基吡啶合成路线

2-氨基-3-甲基吡啶上下游产品

2-氨基-3-甲基吡啶上游产品

2-氨基-3-甲基吡啶下游产品

2-氨基-3-甲基吡啶海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-氨基-3-甲基吡啶文献

Synthesis and characterisation of two novel proton transfer compounds and their inhibition studies on carbonic anhydrase isoenzymes.

J. Enzyme Inhib. Med. Chem. 26(1) , 104-14, (2011)

Two novel proton transfer compounds were prepared between 2,4-dichloro-5-sulphamoylbenzoic acid (lasamide) (Hsba) and ethylenediamine (en), namely ethane-1,2-diaminium 2,4-dichloro-5-sulphamoylbenzoat...

Comutagenesis-III. In vitro metabolism of 2-amino-3-methylpyridine: the effect of various potential inhibitors, activators and inducers.

Xenobiotica 27(11) , 1103-11, (1997)

1. The effects of various potential inhibitors, activators and inducers on the metabolism of the comutagen 2-amino-3-methylpyridine (2A3MP) by rabbit hepatic microsomes and S9 supernatants have been s...

Comutagenesis-I: the in vitro metabolism of 2-amino-3-methylpyridine.

Anticancer Res. 17(5A) , 3485-91, (1997)

The metabolism of the comutagen 2-amino-3-methylpyridine has been studied in vitro using rat and rabbit hepatic preparations. 2-Amino-3-methylpyridine-N-oxide, 2-amino-3-hydroxymethylpyridine and 2-am...

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