PIM-447二盐酸盐

PIM447是泛PIM激酶抑制剂,对PIM1,PIM2,PIM3的 Ki 分别为6,18,9 nM。

信号通路 >> JAK/STAT信号通路 >> 皮姆

研究领域 >> 癌症

[1]. Paíno T et al. The novel pan-PIM kinase inhibitor, PIM447, displays dual anti-myeloma and bone protective effects, and potently synergizes with current standards of care. Clin Cancer Res. 2016 Jul 20.

[2]. Burger MT et al. Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies. J Med Chem. 2015 Nov 12;58(21):8373-86.

[3]. Peters TL et al. Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.Oncotarget. 2016 Aug 20

(5Z)-5-[[2-[(3R)-3-氨基-1-哌啶基][1,1'-联苯]-3-基]亚甲基]-2,4-噻唑烷二酮 | PIM1/AKK1-IN-1 | SGI-1776 | (3E)-5-氯-3-[[5-[3-[(六氢-4-甲基-1H-14-二氮杂革-1-基)羰基]苯基]-2-呋喃]亚甲基]-1,3-二氢-2H-吲哚-2-酮 | TP-3654 | 高车前素 | 3-氰基-4-苯基-6-(3-溴-6-羟基苯基)-2(1H)-吡啶酮 | 5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮 | GDC-0339 | SMI-16A | M-110 | INCB053914磷酸盐 | 槲皮万寿菊素