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组蛋白脱乙酰酶抑制剂

组蛋白脱乙酰酶抑制剂用途

Apicidin (OSI 2040) 是真菌的代谢物, 是一种组蛋白脱乙酰酶 (HDAC) 抑制剂,具有抗寄生虫活性和广谱的抗增殖活性。

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组蛋白脱乙酰酶抑制剂名称

[ CAS 号 ]:
183506-66-3

[ 中文名 ]:
组蛋白脱乙酰酶抑制剂

[ 英文名 ]:
Apicidin

[英文别名 ]:

Acipidin
OSI-2040
Apicidin

组蛋白脱乙酰酶抑制剂生物活性

[ 描述 ]:

Apicidin (OSI 2040) 是真菌的代谢物, 是一种组蛋白脱乙酰酶 (HDAC) 抑制剂,具有抗寄生虫活性和广谱的抗增殖活性。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 细胞周期/DNA损伤 >> HDAC

信号通路 >> 表观遗传学 >> HDAC

[ 靶点 ]

HDAC[1]

[参考文献]

[1]. Han JW, et al. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 2000 Nov 1;60(21):6068-74.

组蛋白脱乙酰酶抑制剂物理化学性质

[ 密度 ]:
1.27g/cm3

[ 分子式 ]:
C₃₄H₄₉N₅O₆

[ 分子量 ]:
609.75600

[ 精确质量 ]:
609.35300

[ PSA ]:
138.84000

[ LogP ]:
4.12130

[ 外观性状 ]:
固体

[ 折射率 ]:
1.615

组蛋白脱乙酰酶抑制剂安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H310-H330

[ 警示性声明 ]:
P260-P264-P280-P284-P302 + P350-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
22-26-36/37/39-45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

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组蛋白脱乙酰酶抑制剂文献

Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth.

PLoS Biol. 12(1) , e1001758, (2014)

Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of ep...

TGF-β1, but not bone morphogenetic proteins, activates Smad1/5 pathway in primary human macrophages and induces expression of proatherogenic genes.

J. Immunol. 194(2) , 709-18, (2015)

Macrophages are responsible for the control of inflammation and healing, and their malfunction results in cardiometabolic disorders. TGF-β is a pleiotropic growth factor with dual (protective and detr...

Determination of the Mycotoxin Content in Distiller's Dried Grain with Solubles Using a Multianalyte UHPLC-MS/MS Method.

J. Agric. Food Chem. 63 , 9441-51, (2015)

There are more than 300 potential mycotoxins that can contaminate food and feed and cause adverse effects in humans and animals. The data on the co-occurrence of mycotoxins in novel animal feed materi...

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