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补骨脂定

补骨脂定用途

补骨脂定(Psoralidin)是从补骨脂中分离出的一种天然呋喃香豆素,具有抗癌活性。

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补骨脂定名称

[ CAS 号 ]:
18642-23-4

[ 中文名 ]:
补骨脂定

[ 英文名 ]:
Psoralidin

[中文别名 ]:

[英文别名 ]:

Psoralidin
3,9-Dihydroxy-2-prenylcoumestan
6-(3-Methylbut-2-enyl)coumestrol

补骨脂定生物活性

[ 描述 ]:

补骨脂定(Psoralidin)是从补骨脂中分离出的一种天然呋喃香豆素,具有抗癌活性。

[ 相关类别 ]:

信号通路 >> 干细胞及 Wnt 通路 >> Notch

天然产物 >> 苯丙酸类

研究领域 >> 癌症

[参考文献]

[1]. Hao W, et al. Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells. PeerJ. 2014 Sep 9;2:e555.

[2]. Liu X, et al. Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1403-6.

[3]. Bronikowska J, et al. The coumarin psoralidin enhances anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Molecules. 2012 May 29;17(6):6449-64.

[4]. Yang HJ, et al. Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation. Biochem Pharmacol. 2011 Sep 1;82(5):524-34.

[相关活性小分子]

补骨脂定物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
458.8±34.0 °C at 760 mmHg

[ 熔点 ]:
290-292°

[ 分子式 ]:
C₂₀H₁₆O₅

[ 分子量 ]:
336.338

[ 闪点 ]:
231.3±25.7 °C

[ 精确质量 ]:
336.099762

[ PSA ]:
83.81000

[ LogP ]:
5.03

[ 外观性状 ]:
white to beige

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.689

[ 储存条件 ]:
?20°C

[ 水溶解性 ]:
DMSO: soluble5mg/mL, clear (warmed)

补骨脂定安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2932999099

补骨脂定合成路线

详细合成路线

补骨脂定上下游产品

补骨脂定上游产品

补骨脂定下游产品

补骨脂定海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

补骨脂定文献

[Study on effect of psoralidin on anti-experimental postmenopausal osteoporosis and its mechanism].

Zhongguo Zhong Yao Za Zhi 38(11) , 1816-9, (2013)

To observe the effect of psoralidine in rats with ovariectomy, and preliminarily study its mechanism.Sixty female Sprague-Dawley rats were divided into 5 groups: the sham operation group, the model gr...

[Study on the chemical constituents of Psoralea corylifolia].

Zhong Yao Cai 34(8) , 1211-3, (2011)

To study the chemical constituents of Psoralea corylifolia.Column chromatography was used in the isolation procedure. The structures of isolated compounds were elucidated by spectral data.Seven compou...

Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.

Biochem. Pharmacol. 82(5) , 524-34, (2011)

Radiotherapy is the most significant non-surgical cure for the elimination of tumor, however it is restricted by two major problems: radioresistance and normal tissue damage. Efficiency improvement on...

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