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桔皮素

桔皮素用途

Tangeretin,黄酮类化合物,是Notch-1的有效抑制剂,具有抗炎,保护神经等作用。

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桔皮素名称

[ CAS 号 ]:
481-53-8

[ 中文名 ]:
桔皮素

[ 英文名 ]:
Tangeretin

[中文别名 ]:

[英文别名 ]:

Ponkanetin
4',5,6,7,8-pentamethoxyflavone
Flavone, 5,6,7,8,4'-pentamethoxy
Flavone, 4',5,6,7,8-pentamethoxy-
TANGERETIN,NATURAL
MFCD00017438
5,6,7,8,4'-Pentamethoxyflavone
TANGARETIN
Tangeritin
Tangeritine

桔皮素生物活性

[ 描述 ]:

Tangeretin,黄酮类化合物,是Notch-1的有效抑制剂,具有抗炎,保护神经等作用。

[ 相关类别 ]:

信号通路 >> 干细胞及 Wnt 通路 >> Notch

研究领域 >> 炎症/免疫

天然产物 >> 黄酮类化合物

[参考文献]

[1]. Zhang X, et al. Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells. Oncol Rep. 2015 Jul;34(1):302-10.

[2]. Xu JJ, et al. Tangeretin from Citrus reticulate Inhibits Respiratory Syncytial Virus Replication and Associated Inflammation in Vivo. J Agric Food Chem. 2015 Nov 4;63(43):9520-7.

[3]. Hagenlocher Y, et al. Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS- and IgE-mediated activation of human intestinal mast cells. Eur J Nutr. 2016 Mar 28.

[相关活性小分子]

桔皮素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
565.3±50.0 °C at 760 mmHg

[ 熔点 ]:
155 °C

[ 分子式 ]:
C₂₀H₂₀O₇

[ 分子量 ]:
372.369

[ 闪点 ]:
248.4±30.2 °C

[ 精确质量 ]:
372.120911

[ PSA ]:
76.36000

[ LogP ]:
2.66

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.566

[ 储存条件 ]:
0-10°C;避免加热

[ 水溶解性 ]:
insoluble

桔皮素MSDS

桔皮素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3102725

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 2-(4-methoxyphenyl)-5,6,7,8-tetramethoxy-

CAS REGISTRY NUMBER :: 481-53-8

BEILSTEIN REFERENCE NO. :: 0351695

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H20-O7

MOLECULAR WEIGHT :: 372.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 3,181,1968

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桔皮素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S45

[ 危险品运输编码 ]:
UN 2811

[ RTECS号 ]:
DJ3102725

[ 危险类别 ]:
6.1

桔皮素合成路线

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桔皮素文献

Phytochemical profile and antioxidant activity of physiological drop of citrus fruits.

J. Food Sci. 78(1) , C37-42, (2013)

The phytochemical content and the antioxidant activity (AA) of physiological drop of the main citrus species grown in China were investigated. Among the flavonoids, hesperidin was found mostly in mand...

Polymethoxylated flavones potentiate the cytolytic activity of NK leukemia cell line KHYG-1 via enhanced expression of granzyme B.

Biochem. Biophys. Res. Commun. 456(3) , 799-803, (2015)

Polymethoxylated flavones (PMFs) are found in the peel tissues of some citrus species. Here, we report that PMFs, such as nobiletin, potentiate the cytolytic activity of KHYG-1 natural killer (NK) leu...

Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice.

Mol. Cell. Endocrinol. 358(1) , 127-34, (2012)

Although the flavonoid tangeretin (5, 6, 7, 8, 4'-pentamethoxyflavone) is known to possess beneficial health effects, the anti-diabetic effects and the mechanism of action have not been elucidated. Tr...

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桔皮素