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放线菌素V

放线菌素V用途

Actinomycin X2 (Actinomycin V) 是由许多链霉菌属物种产生的,对 MRSA 表现出强烈的抑制作用,最小抑菌浓度 (MIC) 值为 0.25 μg/mL。Actinomycin X2 可用于癌症和细菌感染。

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放线菌素V名称

[ CAS 号 ]:
18865-48-0

[ 中文名 ]:
放线菌素V

[ 英文名 ]:
Actinomycin X2

[英文别名 ]:

5'-Deoxy(Methylthio-d3)adenosine
3h-phenoxazine,actinomycindderiv.
[A3-(4-oxo-L-proline)]-actinomycin-D
5'-S-(Methyl-d3)thioadenosine
3a-(4-oxo-l-proline)-actinomycin
5'-(Methylthio-d3)adenosine
actinomycin-V
ACTINOMYCIN X2

放线菌素V生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Zhiyu Chen, et al. Anti-MRSA Activity of Actinomycin X 2 and Collismycin A Produced by Streptomyces globisporusWA5-2-37 From the Intestinal Tract of American Cockroach ( Periplaneta americana). Front Microbiol. 2020 Apr 7;11:555.

放线菌素V物理化学性质

[ 密度 ]:
1.44g/cm3

[ 沸点 ]:
1411.4ºC at 760mmHg

[ 分子式 ]:
C₆₂H₈₄N₁₂O₁₇

[ 分子量 ]:
1269.40000

[ 闪点 ]:
807.4ºC

[ 精确质量 ]:
1268.61000

[ PSA ]:
377.05000

[ LogP ]:
1.55260

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.661

放线菌素V毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU2010000

CHEMICAL NAME :: Actinomycin X2

CAS REGISTRY NUMBER :: 18865-48-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C62-H84-N12-O17

MOLECULAR WEIGHT :: 1269.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 38,1625,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,427,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(2),48,1980

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放线菌素V安全信息

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
26/27/28-63

[ 安全声明 (欧洲) ]:
22-36/37/39-45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2