反式苯亚甲基丙酮

反式苯亚甲基丙酮用途

trans-Benzylideneacetone (trans-Benzalacetone) 是革兰氏阴性致病性线虫细菌嗜线虫 (Xenorhabdus nematophila) 的代谢产物,是针对磷脂酶 A2 (PLA2) 的酶抑制剂。trans-Benzylideneacetone 是一种免疫抑制剂。

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反式苯亚甲基丙酮名称

[ CAS 号 ]:
1896-62-4

[ 中文名 ]:
(E)-苄叉丙酮

[ 英文名 ]:
trans-4-phenylbut-3-en-2-one

[中文别名 ]:

[英文别名 ]:

Benzylideneacetone
benzylidene-2,4,6-trimethylacetophenone
Benzal-3-nitroaniline
trans-4-Phenyl-3-buten-2-one
(E)-4-Phenyl-3-buten-2-one
2',4',6'-Trimethyl-chalkon
N-benzylidene-3-nitro-aniline
Benzal-m-nitroaniline
mesityl styryl ketone
PhCH=NC6H4-NO2-m

反式苯亚甲基丙酮生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷脂

研究领域 >> 炎症/免疫

[ 靶点 ]

PLA2

[体外研究]

苄叉乙酰丙酮(反式苄叉乙酰丙酮；0.005,0.05,0.5,5,50,500,5000μM)抑制甜菜夜蛾幼虫血细胞扩散行为。苄叉丙酮增强苏云金芽孢杆菌对甜菜夜蛾的毒力[1]。

[参考文献]

[1]. Kwon B, et al. Benzylideneacetone, an immunosuppressant, enhances virulence of Bacillus thuringiensisagainst beet armyworm (Lepidoptera: Noctuidae). J Econ Entomol. 2008 Feb;101(1):36-41.

反式苯亚甲基丙酮物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
260.8±9.0 °C at 760 mmHg

[ 熔点 ]:
38.5-41ºC

[ 分子式 ]:
C₁₀H₁₀O

[ 分子量 ]:
146.186

[ 闪点 ]:
65.6±0.0 °C

[ 精确质量 ]:
146.073166

[ PSA ]:
17.07000

[ LogP ]:
2.17

[ 外观性状 ]:
淡黄色低熔点结晶块

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.563

[ 储存条件 ]:
通风低温干燥

[ 水溶解性 ]:
practically insoluble

反式苯亚甲基丙酮MSDS

反式苯亚甲基丙酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EN0330050

CHEMICAL NAME :: 3-Buten-2-one, 4-phenyl-, (E)-

CAS REGISTRY NUMBER :: 1896-62-4

BEILSTEIN REFERENCE NO. :: 0742047

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H10-O

MOLECULAR WEIGHT :: 146.20

WISWESSER LINE NOTATION :: 1V1U1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 300 ug/plate

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,427,1982

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反式苯亚甲基丙酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H317-H319-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
EN0330050

[ 海关编码 ]:
2914399090

反式苯亚甲基丙酮合成路线

反式苯亚甲基丙酮上下游产品

反式苯亚甲基丙酮上游产品

反式苯亚甲基丙酮下游产品

反式苯亚甲基丙酮海关

[ 海关编码 ]: 2914399090

[ 中文概述 ]:
2914399090. 其他不含其他含氧基的芳香酮. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

反式苯亚甲基丙酮文献

Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites.

Arch. Biochem. Biophys. 564 , 244-53, (2014)

The widely used anticoagulant Coumadin (R/S-warfarin) undergoes oxidation by cytochromes P450 into hydroxywarfarins that subsequently become conjugated for excretion in urine. Hydroxywarfarins may mod...

Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents.

J. Nat. Prod. 69 , 1445-9, (2006)

Twenty-eight compounds related to dehydrozingerone (1), isoeugenol (3), and 2-hydroxychalcone (4) were synthesized and evaluated in vitro against human tumor cell replication. Except for isoeugenol an...

Microbial production of 4-hydroxybenzylidene acetone, the direct precursor of raspberry ketone.

Lett. Appl. Microbiol. 45(1) , 29-35, (2007)

To investigate the enzymatic aldol reaction between acetone as a donor and 4-hydroxybenzaldehyde as a receptor to generate 4-(4-hydroxyphenyl)-but-3-ene-2-one or 4-hydroxybenzylidene acetone, the dire...

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