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哈巴俄苷

哈巴俄苷用途

Harpagoside 是从 Harpagophytum procumbens (Hp) 中分离出来的。 Harpagoside 对 COX-1 和 COX-2 活性具有抑制作用,并抑制 NO 的产生。

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哈巴俄苷名称

[ CAS 号 ]:
19210-12-9

[ 中文名 ]:
哈巴俄苷

[ 英文名 ]:
Harpagoside

[中文别名 ]:

[英文别名 ]:

8'-CINNAMOYLHARPAGIDE
Harpagosid
MFCD00017415
8-O-E CINNAMOYL HARPAGIDE
Harpogoside
Einecs 242-881-6

哈巴俄苷生物活性

[ 描述 ]:

Harpagoside 是从 Harpagophytum procumbens (Hp) 中分离出来的。 Harpagoside 对 COX-1 和 COX-2 活性具有抑制作用,并抑制 NO 的产生。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> COX

[ 靶点 ]

COX-1

COX-2

[参考文献]

[1]. Anauate MC, et al. Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay. Phytother Res. 2010 Sep;24(9):1365-9.

哈巴俄苷物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
720.7±60.0 °C at 760 mmHg

[ 熔点 ]:
120ºC (dec.)

[ 分子式 ]:
C₂₄H₃₀O₁₁

[ 分子量 ]:
494.488

[ 闪点 ]:
244.3±26.4 °C

[ 精确质量 ]:
494.178802

[ PSA ]:
175.37000

[ LogP ]:
-0.92

[ 外观性状 ]:
白色至灰白色粉末

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.660

[ 储存条件 ]:
2-8°C

哈巴俄苷MSDS

详细MSDS(安全技术说明书)

哈巴俄苷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
22-45

[ 危险品运输编码 ]:
UN 3172

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哈巴俄苷文献

What the devil is in your phytomedicine? Exploring species substitution in Harpagophytum through chemometric modeling of 1H-NMR and UHPLC-MS datasets.

Phytochemistry 106 , 104-15, (2014)

Harpagophytum procumbens (Pedaliaceae) and its close taxonomical ally Harpagophytum zeyheri, indigenous to southern Africa, are being harvested for exportation to Europe where phytomedicines are devel...

Metabolic differentiations and classification of Verbascum species by NMR-based metabolomics.

Phytochemistry 72(16) , 2045-51, (2011)

The genus Verbascum L. (mulleins) comprises of about 360 species of flowering plants in the Scrophulariaceae family. Mulleins have been used in the traditional folk medicine for centuries, for treatme...

[Simultaneous determination of five constituents in Scrophularia ningpoensis by HPLC].

Zhongguo Zhong Yao Za Zhi 36(6) , 709-11, (2011)

To develop an HPLC method for the simultaneous quantitation of five constituents in Scrophularia ningpoensis.Samples were analyzed on an Agilent SB-C18 column(4.6 mm x 250 mm, 5 microm) eluted with ac...

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