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8-O-乙酰哈巴苷

8-O-乙酰哈巴苷用途

8-O-Acetylharpagide 是从 Ajuga reptans 中分离得到的一种环烯醚萜化合物,具有抗肿瘤、抗病毒、抗菌和抗炎活性。8-O-Acetylharpagide 对豚鼠离体平滑肌也有生物活性。

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8-O-乙酰哈巴苷名称

[ CAS 号 ]:
6926-14-3

[ 中文名 ]:
乙酰哈巴苷

[ 英文名 ]:
8-O-Acetylharpagide

[中文别名 ]:

8-O-乙酰哈巴苷

[英文别名 ]:

6-Thio-8-propylthiotheophylline
8-O-acetyl-harpagide
Harpagide 7-acetyl
Uric acid,1,3-dimethyl-8-propylthio-6-thio
8-n-Propylthio-6-thiotheophyllin

8-O-乙酰哈巴苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Wen B, et al. Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats. J Ethnopharmacol. 2013 May 20;147(2):503-8.

[2]. Breschi MC, et al. Vasoconstrictor activity of 8-O-acetylharpagide from Ajuga reptans. J Nat Prod. 1992 Aug;55(8):1145-8.

8-O-乙酰哈巴苷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
607.2±55.0 °C at 760 mmHg

[ 熔点 ]:
227-229℃

[ 分子式 ]:
C₁₇H₂₆O₁₁

[ 分子量 ]:
406.382

[ 闪点 ]:
215.9±25.0 °C

[ 精确质量 ]:
406.147522

[ PSA ]:
175.37000

[ LogP ]:
-3.48

[ 蒸汽压 ]:
0.0±3.9 mmHg at 25°C

[ 折射率 ]:
1.624

[ 储存条件 ]:
?20°C

8-O-乙酰哈巴苷安全信息

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

8-O-乙酰哈巴苷文献

[Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens extract in beagle dog].

Zhongguo Zhong Yao Za Zhi 38(12) , 2015-8, (2013)

8-O-acetylharpagide and harpagide are two kinds of effective component of Ajuga decumbens extract. A sensitive LC-MS/MS method has been established for pharmacokinetics of 8-O-acetylharpagide and harp...

[Determination of acetylharpagide in Ajuga decumbens by HPLC].

Zhongguo Zhong Yao Za Zhi 31(4) , 289-90, (2006)

To establish a method of the quantitative determination of acetylharpagide in Ajuga decumbens.The chromatographic conditions were as follows: a Phenomenex Luna C18 column was used, the mobile phase wa...

[Studies on chemical constituents of Galeopsis bifida].

Zhongguo Zhong Yao Za Zhi 27(3) , 206-8, (2002)

To investigate the chemical constituents of Galeopsis bifida.Various chromatographic techniques were employed for isolation and purification of the constituents. The structures were elucidated by chem...

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