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3,4-二甲氧基-N-[4-(3-硝基苯基)-2-噻唑基]苯磺酰胺

用途

Ro 61-8048是一种有效的和选择性犬尿氨酸羟化酶(kynurenine hydroxylase)抑制剂,IC50为37 nM。

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名称

[ CAS 号 ]:
199666-03-0

[ 中文名 ]:
3,4-二甲氧基-N-[4-(3-硝基苯基)-2-噻唑基]苯磺酰胺

[ 英文名 ]:
Ro 61-8048

[英文别名 ]:

Ro 61-8048

生物活性

[ 描述 ]:

Ro 61-8048是一种有效的和选择性犬尿氨酸羟化酶(kynurenine hydroxylase)抑制剂,IC50为37 nM。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Rover S, et al. Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem. 1997 Dec 19;40(26):4378-85.

[2]. Cozzi A, et al. Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia. J C

[3]. Hamann M, et al. Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant. Eur J Pharmacol. 2008 May 31;586(1-3):156-9.

[相关活性小分子]

物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
627.4±65.0 °C at 760 mmHg

[ 分子式 ]:
C₁₇H₁₅N₃O₆S₂

[ 分子量 ]:
421.448

[ 闪点 ]:
333.3±34.3 °C

[ 精确质量 ]:
421.040222

[ PSA ]:
159.96000

[ LogP ]:
3.38

[ 外观性状 ]:
light yellow solid

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.641

[ 储存条件 ]:
-20℃

MSDS

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危险品运输编码 ]:
NONH for all modes of transport

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文献

The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.

Eur. J. Pharmacol. 478(1) , 47-52, (2003)

The effects of the novel kynurenine 3-hydroxylase inhibitor 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide (Ro 61-8048) on severity of dystonia were examined in dt(sz) mutant hamste...

Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant.

Eur. J. Pharmacol. 586(1-3) , 156-9, (2008)

Striatal dysfunctions seem to play a key role in the pathophysiology of dystonia in the dt(sz) mutant hamster, a model of paroxysmal non-kinesigenic dyskinesia, in which stress precipitates dystonic e...

The antioxidant role of xanthurenic acid in the Aedes aegypti midgut during digestion of a blood meal.

PLoS ONE 7(6) , e38349, (2012)

In the midgut of the mosquito Aedes aegypti, a vector of dengue and yellow fever, an intense release of heme and iron takes place during the digestion of a blood meal. Here, we demonstrated via chroma...

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3,4-二甲氧基-N-[4-(3-硝基苯基)-2-噻唑基]苯磺酰胺

用途

名称

生物活性

物理化学性质

MSDS

详细MSDS(安全技术说明书)

安全信息

合成路线

详细合成路线

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文献

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