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新蝶呤

新蝶呤用途

D-(+)-Neopterin 是三磷酸腺苷 (GTM) 的分解产物,可以作为细胞免疫系统激活的标志物。

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新蝶呤名称

[ CAS 号 ]:
2009-64-5

[ 中文名 ]:
D-(+)-新蝶呤

[ 英文名 ]:
D-erythro-Neopterin

[中文别名 ]:

[英文别名 ]:

Crithidia Factor
EINECS 217-924-7
D-Neopterin
MFCD00042801
6-(1',2',3'-Trihydroxy)pterin
D(+)-Neopterin 10MG
D(+)-6-(ERYTHRO-1,2,3-TRIHYDROXYPROPYL)PTERIN
D-neopterine
Gavestinel
D-(+)-Neopterin

新蝶呤生物活性

[ 描述 ]:

D-(+)-Neopterin 是三磷酸腺苷 (GTM) 的分解产物,可以作为细胞免疫系统激活的标志物。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

天然产物 >> 糖和糖苷

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Murr C, et al. Neopterin as a Marker for Immune System Activation. Current Drug Metabolism [01 Apr 2002, 3(2):175-187].

[相关活性小分子]

新蝶呤物理化学性质

[ 密度 ]:
2.0±0.1 g/cm3

[ 沸点 ]:
697.7ºC at 760mmHg

[ 熔点 ]:
>232ºC (dec.)

[ 分子式 ]:
C₉H₁₁N₅O₄

[ 分子量 ]:
253.215

[ 闪点 ]:
375.7ºC

[ 精确质量 ]:
253.081100

[ PSA ]:
158.50000

[ LogP ]:
-4.57

[ 外观性状 ]:
灰白色至黄色固体

[ 折射率 ]:
1.860

[ 储存条件 ]:
2~8℃，干燥，密封

新蝶呤MSDS

新蝶呤安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

新蝶呤合成路线

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新蝶呤海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

新蝶呤文献

Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis.

Hum. Immunol. 74(1) , 60-6, (2013)

The Model for End-Stage Liver Disease (MELD) score is a tool for assessment of the degree of hepatic insufficiency/failure. Quinolinic acid (QuinA) is a tryptophan metabolite produced by activated mac...

A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.

Clin. Exp. Immunol. 173(1) , 121-30, (2013)

Circulating neopterin and kynurenine/tryptophan ratio (KTR) increase during inflammation and serve as markers of cellular immune activation, but data are sparse on other determinants of these markers ...

Interferon (IFN)-γ-mediated inflammation and the kynurenine pathway in relation to bone mineral density: the Hordaland Health Study.

Clin. Exp. Immunol. 176(3) , 452-60, (2014)

The risk of osteoporosis increases in inflammatory disorders. In cell-mediated immune activation, interferon (IFN)-γ stimulates macrophage release of neopterin and increases the activity of indoleamin...

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新蝶呤