4-甲基瑞香素

4-甲基瑞香素用途

4-Methyldaphnetin 是合成 4-甲基香豆素衍生物的前体。4-Methyldaphnetin 对几种肿瘤细胞株具有有效、选择性的抗增殖和诱导凋亡的作用。4-Methyldaphnetin 具有清除自由基的作用,对膜脂过氧化有较强的抑制作用。

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4-甲基瑞香素名称

[ CAS 号 ]:
2107-77-9

[ 中文名 ]:
7,8-二羟基-4-甲基香豆素

[ 英文名 ]:
4-Methyldaphnetin

[中文别名 ]:

[英文别名 ]:

4-METHYLDAPHNETIN
7,8-dihydroxy-4-methyl-2H-1-benzopyran-2-one
7,8-Dihydroxy-4-methyl-2H-chromen-2-one
2H-1-Benzopyran-2-one, 7,8-dihydroxy-4-methyl-
EINECS 218-290-4
7,8-dihydroxy-4-methyl-chromen-2-one
7,8-DIHYDROXY-4-METHYLCOUMARIN
4-methyl-7,8-dihydroxycoumarin
Coumarin,7,8-dihydroxy-4-methyl
MFCD00016972

4-甲基瑞香素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Vázquez R, et al. Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21(Cip1/WAF1) as resistance factor. Biochem Pharmacol. 2013 Jul 15;86(2):210-21.

[2]. Jin X, et al. 7,8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression. Neurotox Res. 2015 Apr;27(3):268-74.

[3]. Raj HG, et al. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin. Bioorg Med Chem. 1999 Sep;7(9):2091-4.

4-甲基瑞香素物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
421.5±45.0 °C at 760 mmHg

[ 熔点 ]:
242-246 °C(lit.)

[ 分子式 ]:
C₁₀H₈O₄

[ 分子量 ]:
192.168

[ 闪点 ]:
176.0±22.2 °C

[ 精确质量 ]:
192.042252

[ PSA ]:
70.67000

[ LogP ]:
1.95

[ 外观性状 ]:
固体;White to Light yellow to Light orange powder to crystal

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.652

[ 储存条件 ]:
2-8°C

4-甲基瑞香素MSDS

详细MSDS(安全技术说明书)

4-甲基瑞香素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN6385000

CHEMICAL NAME :: Coumarin, 7,8-dihydroxy-4-methyl-

CAS REGISTRY NUMBER :: 2107-77-9

BEILSTEIN REFERENCE NO. :: 0177613

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H8-O4

MOLECULAR WEIGHT :: 192.18

WISWESSER LINE NOTATION :: T66 BOVJ E1 IQ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04864

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4-甲基瑞香素安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37

[ WGK德国 ]:
3

[ RTECS号 ]:
GN6385000

[ 海关编码 ]:
2932209090

4-甲基瑞香素合成路线

详细合成路线

4-甲基瑞香素上下游产品

4-甲基瑞香素上游产品

4-甲基瑞香素下游产品

4-甲基瑞香素海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%