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派洛宁B

派洛宁B用途

吡咯宁B是一种有机阳离子染料,用于细菌、分枝杆菌和核糖核酸的染色。吡咯宁B也用作一种小的疏水性(SH)蛋白通道抑制剂[1][2]。

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派洛宁B名称

[ CAS 号 ]:
2150-48-3

[ 中文名 ]:
派洛宁B

[ 英文名 ]:
PYRONINE B

[英文别名 ]:

Pyronine B,purified
E tetraethylpyronin
3.6-Bis-diaethylamino-xanthylium-chlorid
Pyronin B
MFCD00011932
EINECS 218-429-9
3,6-bis-diethylamino xanthylium chloride
PYRONINE B

派洛宁B生物活性

[ 描述 ]:

吡咯宁B是一种有机阳离子染料,用于细菌、分枝杆菌和核糖核酸的染色。吡咯宁B也用作一种小的疏水性(SH)蛋白通道抑制剂[1][2]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[体外研究]

在浓度为10μM时,吡咯宁B(0-15μM)抑制约60%的小疏水(SH)蛋白的通道活性,Kd值为6.8μM[1]。Pyronin B(0-0.25μM)以剂量依赖性方式影响Vero细胞中RSV的复制,其TCID 50(50%组织培养感染剂量)在0.25μM[1]浓度下为0。吡咯宁B(10μM)可以与溴酸盐发生氧化反应,并且随着微量Ti(IV)的加入,反应速率急剧增加,特征吸收光谱为555 nm[2]。

[参考文献]

[1]. Yan Li, et al. Inhibition of the human respiratory syncytial virus small hydrophobic protein and structural variations in a bicelle environment. J Virol. 2014 Oct;88(20):11899-914.

[2]. Zhou Z R, et al. Study of the Catalytic Effects of Trace Titanium on Oxidation of Pyronin B with Hydrogen Peroxide and Its Application[C]//Advanced Materials Research. Trans Tech Publications Ltd, 2013, 602: 1233-1237.

派洛宁B物理化学性质

[ 熔点 ]:
174-176ºC

[ 分子式 ]:
C₂₁H₂₇ClN₂O

[ 分子量 ]:
358.905

[ 精确质量 ]:
358.181183

[ PSA ]:
19.39000

[ LogP ]:
1.19980

[ 外观性状 ]:
crystals | Green needles or

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
Soluble in water, ethyl acetate, methyl acetate, ethylene glycol; slightly soluble in ethanol, methanol, methyl cellosolve

派洛宁BMSDS

详细MSDS(安全技术说明书)

派洛宁B毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP6832000

CHEMICAL NAME :: Ammonium, (6-(diethylamino)-3H-xanthen-3-ylidene)diethyl-, chloride

CAS REGISTRY NUMBER :: 2150-48-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C21-H27-N2-O.Cl

MOLECULAR WEIGHT :: 358.95

WISWESSER LINE NOTATION :: T C666 BO EYJ EUK2&2 MN2&2 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 1000 ppm

REFERENCE :: AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1867- Volume(issue)/page/year: 87,295,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3951 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 162 (estimated) No. of Female Employees: 124 (estimated)

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派洛宁B安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R68

[ 安全声明 (欧洲) ]:
S22;S45;S24/25;S36/S37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
BP6832000

派洛宁B合成路线

详细合成路线

派洛宁B上下游产品

派洛宁B上游产品

派洛宁B下游产品

派洛宁B文献

Analysis and testing of biological stains--the Biological Stain Commission Procedures.

Biotech. Histochem. 77(5&6) , 237-275, (2002)

[Fluorescence investigation on interaction between artemisinin (qinghaosu) and hemin and its analytical application].

Guang Pu Xue Yu Guang Pu Fen Xi 26(9) , 1640-3, (2006)

Hemin-catalytic decomposition of artemisinin (qinghaosu, QHS) was studied using pyronine B (PB) as an indicator. The interaction between hemin and QHS was an enzyme-substrate model, and the action sit...

Nuclear dyes and cytoplasmic staining.

Cytometry 29(4) , 375-6, (1997)

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