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硝法唑

硝法唑用途

硝基咪唑是一种4-硝基咪唑衍生物,对参与酒精代谢的乙醛脱氢酶(ALDH)具有强烈而持久的抑制作用。

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硝法唑名称

[ CAS 号 ]:
21721-92-6

[ 中文名 ]:
硝法唑

[ 英文名 ]:
Nitrefazole

[中文别名 ]:

1-(4-硝基苯基)-2-甲基-4-硝基咪唑

[英文别名 ]:

Nitrefazol [INN-Spanish]
2-methyl-4-nitro-1-(4-nitro-phenyl)-1H-imidazole
1-(p-nitrophenyl)-2-methyl-4-nitroimidazole
Nitrefazolum [INN-Latin]
EINECS 244-542-8
BT-985
Nitrefazole
2-Methyl-4-nitro-1-(4-nitrophenyl)imidazol
Altimol
EMD-15,700

硝法唑生物活性

[ 描述 ]:

硝基咪唑是一种4-硝基咪唑衍生物,对参与酒精代谢的乙醛脱氢酶(ALDH)具有强烈而持久的抑制作用。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 醛脱氢酶(ALDH)

研究领域 >> 代谢疾病

[参考文献]

[1]. Koda LY, Madamba SG, Bloom FE. Hypotensive response of ethanol in rats pretreated with disulfiram or nitrefazole. Life Sci. 1984;35(16):1659-1665.

[2]. Zorzano A, Herrera E. Differences in the kinetic properties and sensitivity to inhibitors of human placental, erythrocyte, and major hepatic aldehyde dehydrogenase isoenzymes. Biochem Pharmacol. 1990;39(5):873-878.

硝法唑物理化学性质

[ 密度 ]:
1.53g/cm3

[ 沸点 ]:
484.9ºC at 760 mmHg

[ 分子式 ]:
C₁₀H₈N₄O₄

[ 分子量 ]:
248.19500

[ 闪点 ]:
247.1ºC

[ 精确质量 ]:
248.05500

[ PSA ]:
109.46000

[ LogP ]:
3.04350

[ 蒸汽压 ]:
1.48E-09mmHg at 25°C

[ 折射率 ]:
1.686

硝法唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI7615000

CHEMICAL NAME :: Imidazole, 2-methyl-4-nitro-1-(p-nitrophenyl)-

CAS REGISTRY NUMBER :: 21721-92-6

BEILSTEIN REFERENCE NO. :: 0546441

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H8-N4-O4

MOLECULAR WEIGHT :: 248.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4813 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1119 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5501 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1475 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >6400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 1845 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 8,861,1983

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硝法唑安全信息

[ 海关编码 ]:
2933290090

硝法唑合成路线

详细合成路线

硝法唑上下游产品

硝法唑上游产品

硝法唑下游产品

硝法唑海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

硝法唑