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奈法唑酮盐酸盐

奈法唑酮盐酸盐用途

Nefazodone 盐酸盐是一种抗抑郁药物。

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奈法唑酮盐酸盐名称

[ CAS 号 ]:
82752-99-6

[ 中文名 ]:
萘法唑酮盐酸盐

[ 英文名 ]:
Nefazodone hydrochloride

[中文别名 ]:

[英文别名 ]:

MFCD00865396
Nefazodone Hydrochloride

奈法唑酮盐酸盐生物活性

[ 描述 ]:

Nefazodone 盐酸盐是一种抗抑郁药物。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 神经疾病

[参考文献]

[1]. Bengi Uslu, et al. Electrochemical characterisation of nefazodone hydrochloride and voltammetric determination of the drug in pharmaceuticals and human serum. Analytica Chimica Acta Volume 462, Issue 1, 26 June 2002, Pages 49–57

[2]. SHEN Wei-Yang, et al. Determination of Nefazodone Hydrochloride Tablets by HPLC. Chinese Journal of Pharmaceuticals, 2003-10

[相关活性小分子]

奈法唑酮盐酸盐物理化学性质

[ 沸点 ]:
599.6ºC at 760 mmHg

[ 熔点 ]:
186-188ºC

[ 分子式 ]:
C₂₅H₃₃Cl₂N₅O₂

[ 分子量 ]:
506.46800

[ 闪点 ]:
316.4ºC

[ 精确质量 ]:
505.20100

[ PSA ]:
55.53000

[ LogP ]:
4.35680

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
Desiccate at RT

[ 水溶解性 ]:
DMSO: ~11 mg/mL at 60 °C

奈法唑酮盐酸盐MSDS

奈法唑酮盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

奈法唑酮盐酸盐合成路线

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奈法唑酮盐酸盐文献

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.

J. Chromatogr. A. 1374 , 122-33, (2014)

The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab...

The relation between changes in patients' interpersonal impact messages and outcome in treatment for chronic depression.

J. Consult. Clin. Psychol. 80(3) , 354-64, (2012)

Interpersonal theories posit that chronically depressed individuals have hostile and submissive styles in their social interactions, which may undermine their interpersonal effectiveness and maintain ...

Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug.

Drug Metab. Dispos. 36(6) , 1016-29, (2008)

In vitro metabolism/bioactivation of structurally related central nervous system agents nefazodone (hepatotoxin) and aripiprazole (nonhepatotoxin) were undertaken in human liver microsomes in an attem...

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