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单苯基保泰松

单苯基保泰松用途

莫非布他宗是苯基布他宗(DPB)的一种单苯基类似物,是一种抗炎化合物。莫非布他宗可用于哮喘的研究[1][2]。

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单苯基保泰松名称

[ CAS 号 ]:
2210-63-1

[ 中文名 ]:
单苯基保泰松

[ 英文名 ]:
Mofebutazone

[中文别名 ]:

莫非布宗

[英文别名 ]:

monophenylbutazone
4-Butyl-1-phenylpyrazolidin-3,5-dion
mobutazon
4-butyl-1-phenyl-pyrazolidine-3,5-dione
Mofebutazon
monorheumetten
reumatox
MOFEBUTAZONE
2fdbp
arcomonoltablets

单苯基保泰松生物活性

[ 描述 ]:

莫非布他宗是苯基布他宗(DPB)的一种单苯基类似物,是一种抗炎化合物。莫非布他宗可用于哮喘的研究[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. F.T. Delbeke, et al. Determination of mofebutazone and its 4-hydroxy metabolite in plasma and urine by high-performance liquid chromatography. Journal of Chromatography A. Volume 369, 1986, Pages 440-444

[2]. Khayyal MT,et al. Tolerability of mofebutazone in asthmatic patients. Int J Clin Pharmacol Res. 1995;15(4):145-51.

单苯基保泰松物理化学性质

[ 密度 ]:
1.14g/cm3

[ 分子式 ]:
C₁₃H₁₆N₂O₂

[ 分子量 ]:
232.28

[ 精确质量 ]:
232.12100

[ PSA ]:
49.41000

[ LogP ]:
2.26460

[ 外观性状 ]:
固体

[ 折射率 ]:
1.541

[ 储存条件 ]:
室温

单苯基保泰松MSDS

详细MSDS(安全技术说明书)

单苯基保泰松毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ8420000

CHEMICAL NAME :: 3,5-Pyrazolidinedione, 4-butyl-1-phenyl-

CAS REGISTRY NUMBER :: 2210-63-1

BEILSTEIN REFERENCE NO. :: 0213056

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H16-N2-O2

MOLECULAR WEIGHT :: 232.31

WISWESSER LINE NOTATION :: T5VMNV EHJ CR& E4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 39,155,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 848 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 14,347,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930- Volume(issue)/page/year: 37,185,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 920 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930- Volume(issue)/page/year: 37,185,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 233,365,1958

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单苯基保泰松安全信息

[ 海关编码 ]:
2933990090

单苯基保泰松合成路线

详细合成路线

单苯基保泰松上下游产品

单苯基保泰松上游产品

单苯基保泰松下游产品

单苯基保泰松海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%