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左法哌酯盐酸盐

左法哌酯盐酸盐用途

Levophacetoperane竞争性抑制去甲肾上腺素 (norepinephrin) 摄取和多巴胺 (dopamine) 摄取。

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左法哌酯盐酸盐名称

[ CAS 号 ]:
23257-56-9

[ 中文名 ]:
盐酸左旋茶碱

[ 英文名 ]:
Levophacetoperane (hydrochloride)

[英文别名 ]:

RP 8228
Phenyl-(2-piperidyl)methyl acetate hydrochloride
Levophacetoperan hydrochloride
Lidepran hydrochloride
EINECS 245-536-8
Levophacetoperane hydrochloride
Levophacetoperane (hydrochloride)

左法哌酯盐酸盐生物活性

[ 描述 ]:

Levophacetoperane竞争性抑制去甲肾上腺素 (norepinephrin) 摄取和多巴胺 (dopamine) 摄取。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 多巴胺转运蛋白

研究领域 >> 神经疾病

[ 靶点 ]

Norepinephrin uptake[1] Dopamine uptake[1]

[体外研究]

Levophacetoperane以竞争方式体外抑制大鼠下丘脑和皮质中的去甲肾上腺素摄取,以及纹状体和皮质中的多巴胺摄取。 Levophacetoperane是一种精神兴奋剂[1]。 Levophacetoperane已被用作抗抑郁药和厌食药。 Levophacetoperane是哌甲酯的反向酯。

[参考文献]

[1]. Ramirez A, et al. [Effects of levophacetoperane, pemoline, fenozolone, and centrophenoxine on catecholamines and serotonin uptake in various parts of the rat brain]. C R Acad Sci Hebd Seances Acad Sci D. 1978 Jul 3;187(1):53-6.

[相关活性小分子]

左法哌酯盐酸盐物理化学性质

[ 密度 ]:
1.07g/cm3

[ 沸点 ]:
325.1ºC at 760mmHg

[ 分子式 ]:
C₁₄H₂₀ClNO₂

[ 分子量 ]:
269.76700

[ 闪点 ]:
150.4ºC

[ 精确质量 ]:
269.11800

[ PSA ]:
38.33000

[ LogP ]:
3.56370

[ 储存条件 ]:
-20°C，密闭，干燥

左法哌酯盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN1050000

CHEMICAL NAME :: 2-Piperidinemethanol, alpha-phenyl-, acetate (ester), hydrochloride

CAS REGISTRY NUMBER :: 23257-56-9

LAST UPDATED :: 199012

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C14-H19-N-O2.Cl-H

MOLECULAR WEIGHT :: 269.80

WISWESSER LINE NOTATION :: T6MTJ DYR&OV1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 390 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 241,182,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 77 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,254,1972

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左法哌酯盐酸盐安全信息

[ 海关编码 ]:
2933399090

左法哌酯盐酸盐海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%