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梓醇

梓醇用途

梓醇 (Catalpol) 是一种环烯醚萜苷,具有神经保护、抗炎及抗病毒性肝炎的作用。

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梓醇名称

[ CAS 号 ]:
2415-24-9

[ 中文名 ]:
梓醇

[ 英文名 ]:
Catalpol

[中文别名 ]:

脱对轻基苯甲酸梓昔

[英文别名 ]:

EINECS 219-324-0
catalpinoside
des-p-hydroxybenzoyl-catalposid
CATAPOL
catalposide
methyl iridoid glycoside

梓醇生物活性

[ 描述 ]:

梓醇 (Catalpol) 是一种环烯醚萜苷,具有神经保护、抗炎及抗病毒性肝炎的作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 萜类化合物和糖苷

研究领域 >> 其他

[参考文献]

[1]. Zhao M, et al.Comparative pharmacokinetics of catalpol and acteoside in normal and chronic kidney disease rats after oral administration of Rehmannia glutinosa extract. Biomed Chromatogr. 2015 May 29.

[2]. Guo JH, et al.Potential Neurogenesis of Human Adipose-Derived Stem Cells on Electrospun Catalpol-Loaded Composite Nanofibrous Scaffolds. Ann Biomed Eng. 2015 Mar 31.

[3]. Zhu J,Catalpol protects mice against renal ischemia/reperfusion injury via suppressing PI3K/Akt-eNOS signaling and inflammation. Int J Clin Exp Med. 2015 Feb 15;8(2):2038-44.

[4]. Xu Z, et al.Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose-induced hepatic mitochondrial dysfunction. Acta Biochim Biophys Sin (Shanghai). 2015 Jul 2.

[相关活性小分子]

梓醇物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
675.6±55.0 °C at 760 mmHg

[ 熔点 ]:
203-205ºC

[ 分子式 ]:
C₁₅H₂₂O₁₀

[ 分子量 ]:
362.329

[ 闪点 ]:
362.4±31.5 °C

[ 精确质量 ]:
362.121307

[ PSA ]:
161.60000

[ LogP ]:
-4.15

[ 蒸汽压 ]:
0.0±4.7 mmHg at 25°C

[ 折射率 ]:
1.679

[ 储存条件 ]:
?20°C

梓醇MSDS

梓醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ5776816

CHEMICAL NAME :: beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy- 1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran- 2-yl, (1aS-(1a-alpha,1b-beta,2-beta,5a- beta,6-beta,6a-alpha))-

CAS REGISTRY NUMBER :: 2415-24-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H22-O10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,93,1968

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,93,1968

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梓醇安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
LZ5776816

梓醇合成路线

梓醇上下游产品

梓醇上游产品

梓醇下游产品

梓醇制备

用二乙基酮与1-氨基乙烯基甲基酮反应制得。

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梓醇文献

HPLC-APCI-MS/MS method for the determination of catalpol in rat plasma and cerebrospinal fluid: application to an in vivo pharmacokinetic study.

J. Pharm. Biomed. Anal. 70 , 337-43, (2012)

Catalpol is a Chinese herb ingredient with potential for the treatment of neurodegenerative disorders. A high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spe...

[Simultaneous determination and optimization of extraction process of catalpol and acteoside from rehmanniae radix].

Zhong Yao Cai 35(8) , 1318-22, (2012)

To establish a method for simultaneously quantification of the Catalpol and Acteoside from Rehmanniae Radix and optimize the extraction process from Rehmanniae Radix by response surface methodology (R...

Synergistic effects of iridoid glycosides on the survival, development and immune response of a specialist caterpillar, Junonia coenia (Nymphalidae).

J. Chem. Ecol. 38(10) , 1276-84, (2012)

Plants use a diverse mix of defenses against herbivores, including multiple secondary metabolites, which may affect herbivores synergistically. Chemical defenses also can affect natural enemies of her...

更多文献

梓醇

梓醇用途

梓醇名称

梓醇生物活性

梓醇物理化学性质

梓醇MSDS

详细MSDS(安全技术说明书)

梓醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

梓醇安全信息

梓醇合成路线

详细合成路线

梓醇上下游产品

梓醇上游产品

梓醇下游产品

梓醇制备

梓醇文献

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