格洛沙腙
格洛沙腙用途
Gloxazone是一种有效但有毒的无血浆药[1]。
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格洛沙腙名称
[ CAS 号 ]:
2507-91-7
[ 中文名 ]:
格洛沙腙
[ 英文名 ]:
gloxazone
[英文别名 ]:
- WR 9838
- Gloxazon
- 2-Keto-3-aethoxy-butyraldehyd-bis-thiosemicarbazon
- 3-Aethoxy-2-keto-butyraldehyd-bis-thiosemicarbazon
- GLOXAZONE
- BW 356C61
- KTS,pharmaceutical
- KC 1331
- KTS
- 3-Aethoxy-butan-1,2-dion-bis-thiosemicarbazon
格洛沙腙生物活性
[ 描述 ]:
Gloxazone是一种有效但有毒的无血浆药[1]。
[ 相关类别 ]:
[体内研究]
格列沙酮(5 mg/kg；静脉注射)对人工感染 边缘Anaplama的阉牛有效[1]。 格列沙酮(0.1-3 mg/kg/天；口服)引起大鼠肾乳头状坏死和肾毒性[1]。
[参考文献]
格洛沙腙物理化学性质
[ 密度 ]:
1.41g/cm3
[ 沸点 ]:
419.7ºC at 760mmHg
[ 分子式 ]:
C8H16N6OS2
[ 分子量 ]:
276.38200
[ 闪点 ]:
207.6ºC
[ 精确质量 ]:
276.08300
[ PSA ]:
174.23000
[ LogP ]:
1.60200
[ 蒸汽压 ]:
2.97E-07mmHg at 25°C
[ 折射率 ]:
1.645
格洛沙腙毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ES2450000
- CHEMICAL NAME :
- Butyraldehyde, 3-ethoxy-2-oxo-, bis(thiosemicarbazone)
- CAS REGISTRY NUMBER :
- 2507-91-7
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C8-H16-N6-O-S2
- MOLECULAR WEIGHT :
- 276.42
- WISWESSER LINE NOTATION :
- SUYZMNUYY1&O2&1UNMYZUS
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >3200 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 440 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 195 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 182 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1600 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 475 mg/kg/5D-I
- TOXIC EFFECTS :
- Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 190 mg/kg/5D-I
- TOXIC EFFECTS :
- Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg/5D-I
- TOXIC EFFECTS :
- Behavioral - ataxia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 100 mg/kg/10D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 90 mg/kg/30D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 250 mg/kg/10D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 300 mg/kg/10D-I
- TOXIC EFFECTS :
- Behavioral - coma Endocrine - hypoglycemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 300 mg/kg/30D-I
- TOXIC EFFECTS :
- Endocrine - hypoglycemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human HeLa cell
- DOSE/DURATION :
- 50 umol/l
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 92,427,1982
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格洛沙腙安全信息
[ 海关编码 ]:
2930909090
格洛沙腙合成路线
格洛沙腙上下游产品
格洛沙腙上游产品
格洛沙腙下游产品
格洛沙腙海关
[ 海关编码 ]: 2930909090
[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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相关化合物
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