维洛沙秦
维洛沙秦用途
维洛嗪(维洛嗪)是一种去甲肾上腺素再摄取抑制剂,也是一种有效的5-HT2C激动剂和5-HT2B拮抗剂,其EC50分别为32μM和27μM。维洛嗪的作用机制主要涉及5-羟色胺能和去甲肾上腺素能途径。维洛嗪可用于研究抑郁症[1][2]。
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维洛沙秦名称
[ CAS 号 ]:
46817-91-8
[ 中文名 ]:
维洛沙秦
[ 英文名 ]:
2-[(2-ethoxyphenoxy)methyl]morpholine
[中文别名 ]:
[英文别名 ]:
- Emovit
- Morpholine,2-((2-ethoxyphenoxy)methyl)
- Viloxazinum [INN-Latin]
- 2-(2-Ethoxy-phenoxymethyl)-morpholine
- 2-(o-ethoxyphenoxymethyl)morpholine
- viloxazine
- Viloxazina [INN-Spanish]
- Viloxazin
维洛沙秦生物活性
[ 描述 ]:
维洛嗪(维洛嗪)是一种去甲肾上腺素再摄取抑制剂,也是一种有效的5-HT2C激动剂和5-HT2B拮抗剂,其EC50分别为32μM和27μM。维洛嗪的作用机制主要涉及5-羟色胺能和去甲肾上腺素能途径。维洛嗪可用于研究抑郁症[1][2]。
[ 相关类别 ]:
[ 靶点 ]
Human 5-HT2C Receptor:32 μM (EC50)
human 5-HT2B Receptor:27 μM (IC50)
[参考文献]
维洛沙秦物理化学性质
[ 密度 ]:
1.061 g/cm3
[ 沸点 ]:
350.5ºC at 760 mmHg
[ 熔点 ]:
185-186ºC
[ 分子式 ]:
C13H19NO3
[ 分子量 ]:
237.29500
[ 闪点 ]:
144.3ºC
[ 精确质量 ]:
237.13600
[ PSA ]:
39.72000
[ LogP ]:
1.78130
[ 折射率 ]:
1.499
维洛沙秦毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QE3940000
- CHEMICAL NAME :
- Morpholine, 2-((2-ethoxyphenoxy)methyl)-
- CAS REGISTRY NUMBER :
- 46817-91-8
- LAST UPDATED :
- 199403
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C13-H19-N-O3
- MOLECULAR WEIGHT :
- 237.33
- WISWESSER LINE NOTATION :
- T6M DOTJ C1OR BO2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity
- REFERENCE :
- HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity
- REFERENCE :
- HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 552 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 27,437,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity
- REFERENCE :
- HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 130 mg/kg
- SEX/DURATION :
- female 8-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 7,504,1984
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