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聚乙二醇

聚乙二醇用途

PEG300 是一种中性的生物相容性亲水聚合物。

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聚乙二醇名称

[ CAS 号 ]:
25322-68-3

[ 中文名 ]:
聚乙二醇

[ 英文名 ]:
Poly(ethylene glycol)

[中文别名 ]:

[英文别名 ]:

EINECS 203-473-3
Polyethylene glycol 10000
Poly(ethylene oxide),approx. M.W. 900,000
Polyethylene glycol 1000
Poly(ethylene glycol),average M.W. 200
Polyethylene glycol 12000
Polyethylene glycol (PEG)
Poly(ethylene glycol)
Poly(ethylene g
Macrogol 300,PEG

聚乙二醇生物活性

[ 描述 ]:

PEG300 是一种中性的生物相容性亲水聚合物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

生化试剂

[参考文献]

[1]. Bakar B, et al. Evaluation of the neurotoxicity of the polyethylene glycol hydrogel dural sealant. Turk Neurosurg. 2013;23(1):16-24.

[相关活性小分子]

聚乙二醇物理化学性质

[ 密度 ]:
1.125

[ 沸点 ]:
250ºC

[ 熔点 ]:
-65ºC

[ 分子式 ]:
C₅H₁₂O₂

[ 分子量 ]:
104.15

[ 闪点 ]:
171ºC

[ 外观性状 ]:
透明无色粘性液体

[ 蒸汽密度 ]:
>1 (vs air)

[ 蒸汽压 ]:
<0.01 mm Hg ( 20 °C)

[ 折射率 ]:
1.458-1.461

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
H2O: 50 mg/mL, clear, colorless

聚乙二醇MSDS

详细MSDS(安全技术说明书)

聚乙二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TQ4025000

CHEMICAL NAME :: Polyethylene glycol #1000

CAS REGISTRY NUMBER :: 25322-68-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1413,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640) Volume(issue)/page/year: MSD-937

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15570 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 3,451,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,293,1951

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,293,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640) Volume(issue)/page/year: MSD-937

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 22500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 39,349,1950 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 416 mg/kg/Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - other reproductive system tumors

REFERENCE :: BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 15,252,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0788 No. of Facilities: 60 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 1675 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80189 No. of Facilities: 34023 (estimated) No. of Industries: 237 No. of Occupations: 159 No. of Employees: 487377 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7669 No. of Facilities: 37662 (estimated) No. of Industries: 225 No. of Occupations: 183 No. of Employees: 1335913 (estimated) No. of Female Employees: 861947 (estimated)

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聚乙二醇安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H311-H373-H411

[ 警示性声明 ]:
P273-P280-P301 + P312 + P330-P302 + P352 + P312-P391-P501

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TQ4110000

[ 海关编码 ]:
3404900000

聚乙二醇制备

1.乙二醇在催化剂的存在下与环氧乙烷聚合而成。

2.环氧乙烷在异丙醇铝催化下自聚而成。

3.将120#汽油加入反应釜中，在搅拌下加入异丙醇铝作催化剂（催化剂量为单体总量的1.01-1.03%）。用氮气置换釜中空气后，加入单体环氧乙烷（溶剂∶环氧乙烷＝2∶1，质量比）。在10～20℃下反应4h 。然后逐渐升温至35～40℃，再反应3h。聚合反应结束。将物料转移至蒸馏釜中，蒸出溶剂，冷却析晶，过滤，得粗产品。真空干燥得成品。反应式如下：

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聚乙二醇海关

[ 海关编码 ]: 3404900000

聚乙二醇文献

A Comparison of the α2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain.

Adv. Pharmacol. Sci. 2011 , 608912, (2011)

GABA(A) receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result i...

PDADMAC flocculation of Chinese hamster ovary cells: enabling a centrifuge-less harvest process for monoclonal antibodies.

MAbs 7(2) , 413-28, (2015)

High titer (>10 g/L) monoclonal antibody (mAb) cell culture processes are typically achieved by maintaining high viable cell densities over longer culture durations. A corresponding increase in the so...

Localized experimental bone metastasis drives osteolysis and sensory hypersensitivity at distant non-tumor-bearing sites.

Breast Cancer Res. Treat. 153 , 9-20, (2015)

Patients with breast cancer metastasis to bone suffer from inadequate pain relief. Animal models provide increased understanding of cancer-induced bone and sensory alterations. The objective of this s...

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聚乙二醇相关知识

聚乙二醇的用途和合成方法

2022-05-24 18:36:54

聚乙二醇，别名氧化聚乙烯，是一种高分子聚合物，其化学结构式为HO(CH2CH2O)nH ，n是大于4的整数，因此，聚乙二醇的相对分子量从200-7000不等，日常使用时，为了进行区分，通常会在名称后面加数字，比如聚乙二醇-300就表示分子量为300的聚乙二醇。聚乙二醇水溶性良好，和很多有机物具备良...

聚乙二醇

聚乙二醇用途

聚乙二醇名称

聚乙二醇生物活性

聚乙二醇物理化学性质

聚乙二醇MSDS

详细MSDS(安全技术说明书)

聚乙二醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

聚乙二醇安全信息

聚乙二醇制备

聚乙二醇海关

聚乙二醇文献

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