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酸性红18

酸性红18用途

Ponceau 4R是一种合成的着色剂, 可用于食品着色, Ponceau 4R是草莓红偶氮染料, 可以在各种食品中使用, 通常是从芳族烃合成, 对光, 热, 和酸稳定。

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酸性红18名称

[ CAS 号 ]:
2611-82-7

[ 中文名 ]:
酸性红 18

[ 英文名 ]:
Ponceau 4R

[中文别名 ]:

[英文别名 ]:

EINECS 220-036-2
l-rot4
AcidredR
Brilliant ponceau 5R
foodred7
1578red
Ponceau 4 R
E124
foodred6
COCCINE

酸性红18生物活性

[ 描述 ]:

Ponceau 4R是一种合成的着色剂, 可用于食品着色, Ponceau 4R是草莓红偶氮染料, 可以在各种食品中使用, 通常是从芳族烃合成, 对光, 热, 和酸稳定。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

染料试剂

研究领域 >> 其他

[相关活性小分子]

酸性红18物理化学性质

[ 分子式 ]:
C₂₀H₁₁N₂Na₃O₁₀S₃

[ 分子量 ]:
604.473

[ 精确质量 ]:
603.926880

[ PSA ]:
241.69000

[ LogP ]:
6.06870

[ 外观性状 ]:
红色粉末

[ 储存条件 ]:
室温，干燥，惰性气体氛围

酸性红18MSDS

详细MSDS(安全技术说明书)

酸性红18毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ6530000

CHEMICAL NAME :: 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthalenyl)azo)-, trisodium salt

CAS REGISTRY NUMBER :: 2611-82-7

LAST UPDATED :: 199709

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C20-H14-N2-O10-S3.3Na

MOLECULAR WEIGHT :: 607.51

WISWESSER LINE NOTATION :: L66J CO HSWO JSWO BNUN- BL66J ESWO &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 143 gm/kg/90D-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 gm/kg/30D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 48 mg/m3/17W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Liver - liver function tests impaired Blood - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 428 gm/kg/64W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 1 gm/L

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4494 No. of Facilities: 46 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 138 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4494 No. of Facilities: 1035 (estimated) No. of Industries: 5 No. of Occupations: 9 No. of Employees: 8379 (estimated) No. of Female Employees: 2006 (estimated)

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酸性红18安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
QJ6530000

[ 海关编码 ]:
32041200

酸性红18制备

1. 以 1，4-氨基萘磺酸和G 酸(2-naphthol-6,8-disulfonic acid) 为原料，将1,4-氨基萘磺酸重氮化，与G 酸偶合得产物。经盐析，过滤，干燥，粉碎得成品。

2. 由4-氨基-1-萘磺酸(naphthionic acid)重氮化，与2-萘酚-6,8-二磺酸钠偶合反应后用氯化钠盐析，经精制而得。

3.胭脂红的制备
将1-萘胺-4-磺酸钠溶解于8～9倍量(质量)75～85℃的水，过滤、冷却至0～5℃；然后加入原钠盐1.2～1.5倍量(质量)的盐酸，搅匀静置，析出细微的1-萘胺-4-磺酸结晶，并将其冷却至5℃以下；在3～5℃下缓缓加入1：2(质量)的亚硝酸钠溶液进行重氮化，得微黄色糊状重氮液，反应完毕后料液对刚果红试纸呈强酸性(显蓝色)。
将G酸钠(2-萘酚-6,8-二磺酸钠)搅拌溶解于9～10倍量(质量)60～65℃的水中，再加入部分碳酸钠(总量的1/5)，溶解后过滤；滤液投入反应釜内，然后加入其余的碳酸钠，搅拌并冷却至5～8℃，再在10～15℃和pH值为8时，缓缓加入重氮液进行偶合反应数小时。反应完毕后(2-萘酚-6,8-二磺酸钠略为过量)将其升温至50～60℃，加入精制氯化钠，搅拌，并使其自然冷却至室温，静置析出结晶。将结晶搅拌溶解于15倍量(质量)70℃的洁净水中，加入适量的碳酸钠，使溶液呈微碱性。过滤后加入精盐，搅拌并用盐酸调pH值至6.5～7.0，静置结晶、分离干燥得产品。
胭脂红铝色淀的制备
由氯化铝、硫酸铝等的铝盐与碳酸钠等的碱类制取氢氧化铝，添加于胭脂红水溶液，沉淀而得产品。

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酸性红18文献

Influence of synthetic and natural food dyes on activities of CYP2A6, UGT1A6, and UGT2B7.

J. Toxicol. Environ. Health A 68(16) , 1431-44, (2005)

Synthetic or natural food dyes are typical xenobiotics, as are drugs and pollutants. After ingestion, part of these dyes may be absorbed and metabolized by phase I and II drug-metabolizing enzymes and...

Pattern of intake of food additives associated with hyperactivity in Irish children and teenagers.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 27(4) , 447-56, (2010)

A double-blind randomized intervention study has previously shown that a significant relationship exists between the consumption of various mixes of seven target additives by children and the onset of...

Toxicity of xanthene food dyes by inhibition of human drug-metabolizing enzymes in a noncompetitive manner.

J. Environ. Public Health 2009 , 953952, (2009)

The synthetic food dyes studied were rose bengal (RB), phroxine (PL), amaranth, erythrosine B (ET), allura red, new coccine, acid red (AR), tartrazine, sunset yellow FCF, brilliant blue FCF, and indig...

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酸性红18

酸性红18用途

酸性红18名称

酸性红18生物活性

酸性红18物理化学性质

酸性红18MSDS

详细MSDS(安全技术说明书)

酸性红18毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

酸性红18安全信息

酸性红18制备

酸性红18文献

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